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Toxins 2018, 10(1), 25; doi:10.3390/toxins10010025

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

Institute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan
Graduate Institute of Food Science Technology, National Taiwan University, Taipei 10617, Taiwan
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Authors to whom correspondence should be addressed.
Received: 10 November 2017 / Revised: 28 December 2017 / Accepted: 28 December 2017 / Published: 2 January 2018
(This article belongs to the Section Mycotoxins)
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Aflatoxin B1 (AFB1), among other aflatoxins of the aflatoxin family, is the most carcinogenic and hazardous mycotoxin to animals and human beings with very high potency leading to aflatoxicosis. Selenium is an essential trace mineral possessing powerful antioxidant functions. Selenium is widely reported as an effective antioxidant against aflatoxicosis. By preventing oxidative liver damage, suppressing pro-apoptotic proteins and improving immune status in AFB1 affected animals; selenium confers specific protection against AFB1 toxicity. Meticulous supplementation of animal feed by elemental selenium in the organic and inorganic forms has proven to be effective to ameliorate AFB1 toxicity. Curcumin is another dietary agent of importance in tackling aflatoxicosis. Curcumin is one of the major active ingredients in the tubers of a spice Curcuma longa L., a widely reported antioxidant, anticarcinogenic agent with reported protective potential against aflatoxin-mediated liver damage. Curcumin restricts the aflatoxigenic potential of Aspergillus flavus. Curcumin inhibits cytochrome P450 isoenzymes, particularly CYP2A6 isoform; thereby reducing the formation of AFB1-8, 9-epoxide and other toxic metabolites causing aflatoxicosis. In this review, we have briefly reviewed important aflatoxicosis symptoms among animals. With the main focus on curcumin and selenium, we have reviewed their underlying protective mechanisms in different animals along with their extraction and production methods for feed applications. View Full-Text
Keywords: aflatoxin B1; anti-AFB1 dietary supplement; curcumin; selenium; antioxidant status aflatoxin B1; anti-AFB1 dietary supplement; curcumin; selenium; antioxidant status

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Limaye, A.; Yu, R.-C.; Chou, C.-C.; Liu, J.-R.; Cheng, K.-C. Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review. Toxins 2018, 10, 25.

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