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Toxins 2009, 1(2), 162-172; doi:10.3390/toxins1020162

Isolation and Chemical Characterization of a Toxin Isolated from the Venom of the Sea Snake, Hydrophis torquatus aagardi

1
Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan
2
Department of Biochemistry and Molecular Biology, Colorado State University, Ft. Collins, CO 80523, USA
*
Author to whom correspondence should be addressed.
Received: 28 October 2009 / Revised: 2 December 2009 / Accepted: 7 December 2009 / Published: 8 December 2009
(This article belongs to the Special Issue Neurotoxins of Biological Origin)
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Abstract

Sea snakes (family: Hydrophiidae) are serpents found in the coastal areas of the Indian and Pacific Oceans. There are two subfamilies in Hydrophiidae: Hydrophiinae and Laticaudinae. A toxin, aagardi toxin, was isolated from the venom of the Hydrophiinae snake, Hydrophis torquatus aagardi and its chemical properties such as molecular weight, isoelectric point, importance of disulfide bonds, lack of enzymatic activity and amino acid sequence were determined. The amino acid sequence indicated a close relationship to the primary structure of other Hydrophiinae toxins and a significant difference from Laticaudinae toxins, confirming that primary toxin structure is closely related to sea snake phylogenecity. View Full-Text
Keywords: Hydrophiidae toxin; Hydrophis torquatus aagardi toxin; sea snake toxin Hydrophiidae toxin; Hydrophis torquatus aagardi toxin; sea snake toxin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nagamizu, M.; Komori, Y.; Uchiya, K.-I.; Nikai, T.; Tu, A.T. Isolation and Chemical Characterization of a Toxin Isolated from the Venom of the Sea Snake, Hydrophis torquatus aagardi. Toxins 2009, 1, 162-172.

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