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Toxins 2009, 1(2), 162-172; doi:10.3390/toxins1020162
Article

Isolation and Chemical Characterization of a Toxin Isolated from the Venom of the Sea Snake, Hydrophis torquatus aagardi

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Received: 28 October 2009 / Revised: 2 December 2009 / Accepted: 7 December 2009 / Published: 8 December 2009
(This article belongs to the Special Issue Neurotoxins of Biological Origin)
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Abstract

Sea snakes (family: Hydrophiidae) are serpents found in the coastal areas of the Indian and Pacific Oceans. There are two subfamilies in Hydrophiidae: Hydrophiinae and Laticaudinae. A toxin, aagardi toxin, was isolated from the venom of the Hydrophiinae snake, Hydrophis torquatus aagardi and its chemical properties such as molecular weight, isoelectric point, importance of disulfide bonds, lack of enzymatic activity and amino acid sequence were determined. The amino acid sequence indicated a close relationship to the primary structure of other Hydrophiinae toxins and a significant difference from Laticaudinae toxins, confirming that primary toxin structure is closely related to sea snake phylogenecity.
Keywords: Hydrophiidae toxin; Hydrophis torquatus aagardi toxin; sea snake toxin Hydrophiidae toxin; Hydrophis torquatus aagardi toxin; sea snake toxin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nagamizu, M.; Komori, Y.; Uchiya, K.-I.; Nikai, T.; Tu, A.T. Isolation and Chemical Characterization of a Toxin Isolated from the Venom of the Sea Snake, Hydrophis torquatus aagardi. Toxins 2009, 1, 162-172.

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