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Nutrients 2017, 9(9), 978; doi:10.3390/nu9090978

A Novel Combination of Wheat Peptides and Fucoidan Attenuates Ethanol-Induced Gastric Mucosal Damage through Anti-Oxidant, Anti-Inflammatory, and Pro-Survival Mechanisms

1
Nutrilite Health Institute, 720 Cailun Road, Shanghai 201203, China
2
Nutrilite Health Institute, 7575 East Fulton Avenue, Ada, MI 49355, USA
3
Nutrilite Health Institute, 5600 Beach Boulevard, Buena Park, CA 90621, USA
4
China National Research Institute of Food and Fermentation Industries, 24 Jiuxianqiao Middle Road, Beijing 100015, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 13 July 2017 / Revised: 29 August 2017 / Accepted: 29 August 2017 / Published: 6 September 2017
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Abstract

Gastritis or peptic ulcer is believed to affect about half of people worldwide. Traditional medications can lead to adverse effects, therefore, alternative nutritional strategies are needed to prevent the development of gastric mucosal damage. A novel combination of two food-grade ingredients, wheat peptides and fucoidan (WPF), was prepared to treat male Sprague Dawley rats for 30 days before gastric mucosal damage was induced by oral administration of ethanol. The serum levels of biomarkers were determined by enzyme-linked immunosorbent assay. Biomarkers in stomach tissue were analyzed using immunohistochemistry. In addition, human gastric epithelial cell line (GES-1) was used to investigate protein expression by Western blot. WPF could attenuate ethanol-induced gastric mucosal damage in an inverse dose-dependent manner, with both ulcer index and pathological index improved. WPF increased superoxide dismutase level and decreased malondialdehyde level. WPF also decreased the levels of interleukin-8, platelet-activating factor, and Caspase 3, while increasing the levels of prostaglandin E-2, epidermal growth factor (EGF), and EGF receptor (EGFR). Furthermore, phosphorylation of EGFR and extracellular signal–regulated kinases was induced by WPF in GES-1 cells. In conclusion, the novel combination of wheat peptides and fucoidan attenuated ethanol-induced gastric mucosal damage in rats through anti-oxidant, anti-inflammatory, and pro-survival mechanisms. View Full-Text
Keywords: gastric mucosal damage; wheat peptides; fucoidan; anti-oxidant; anti-inflammation; pro-survival gastric mucosal damage; wheat peptides; fucoidan; anti-oxidant; anti-inflammation; pro-survival
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MDPI and ACS Style

Kan, J.; Hood, M.; Burns, C.; Scholten, J.; Chuang, J.; Tian, F.; Pan, X.; Du, J.; Gui, M. A Novel Combination of Wheat Peptides and Fucoidan Attenuates Ethanol-Induced Gastric Mucosal Damage through Anti-Oxidant, Anti-Inflammatory, and Pro-Survival Mechanisms. Nutrients 2017, 9, 978.

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