Next Article in Journal
Personalised Interventions—A Precision Approach for the Next Generation of Dietary Intervention Studies
Next Article in Special Issue
The Role of Nutritional Aspects in Food Allergy: Prevention and Management
Previous Article in Journal
In Vitro and In Vivo Evaluation of Lactobacillus delbrueckii subsp. bulgaricus KLDS1.0207 for the Alleviative Effect on Lead Toxicity
Previous Article in Special Issue
Diet Quality throughout Early Life in Relation to Allergic Sensitization and Atopic Diseases in Childhood
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Nutrients 2017, 9(8), 854; doi:10.3390/nu9080854

Role of Microbial Modulation in Management of Atopic Dermatitis in Children

1
Department of Paediatric Respiratory Medicine and Allergy, Emma Children’s Hospital Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
2
Department of Paediatric Immunology, University Medical Center Utrecht/Wilhelmina Children’s Hospital, 3584 EA Utrecht, The Netherlands
3
Nutricia Research, 3584 CT Utrecht, The Netherlands
4
Department of Paediatric Pulmonology and Paediatric Allergology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
5
Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands
These authors contributed equally to this paper.
*
Author to whom correspondence should be addressed.
Received: 31 May 2017 / Revised: 27 July 2017 / Accepted: 3 August 2017 / Published: 9 August 2017
(This article belongs to the Special Issue Nutrition and Allergic Diseases)
View Full-Text   |   Download PDF [271 KB, uploaded 10 August 2017]

Abstract

The pathophysiology of atopic dermatitis (AD) is multifactorial and is a complex interrelationship between skin barrier, genetic predisposition, immunologic development, skin microbiome, environmental, nutritional, pharmacological, and psychological factors. Several microbial modulations of the intestinal microbiome with pre- and/or probiotics have been used in AD management, with different clinical out-come (both positive, as well as null findings). This review provides an overview of the clinical evidence from trials in children from 2008 to 2017, aiming to evaluate the effect of dietary interventions with pre- and/or pro-biotics for the treatment of AD. By searching the PUBMED/MEDLINE, EMBADE, and COCHRANE databases 14 clinical studies were selected and included within this review. Data extraction was independently conducted by two authors. The primary outcome was an improvement in the clinical score of AD severity. Changes of serum immunological markers and/or gastrointestinal symptoms were explored if available. In these studies some dietary interventions with pre- and/or pro-biotics were beneficial compared to control diets in the management of AD in children, next to treatment with emollients, and/or local corticosteroids. However, heterogeneity between studies was high, making it clear that focused clinical randomized controlled trials are needed to understand the potential role and underlying mechanism of dietary interventions in children with AD. View Full-Text
Keywords: atopic dermatitis; children; mucosal immune development atopic dermatitis; children; mucosal immune development
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hulshof, L.; van’t Land, B.; Sprikkelman, A.B.; Garssen, J. Role of Microbial Modulation in Management of Atopic Dermatitis in Children. Nutrients 2017, 9, 854.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top