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Nutrients 2017, 9(8), 841; doi:10.3390/nu9080841

Diet Quality throughout Early Life in Relation to Allergic Sensitization and Atopic Diseases in Childhood

1
Department of Epidemiology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
2
The Generation R Study Group, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
3
Department of Dermatology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
4
Department of Pediatrics, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
5
Department of Global Public Health, Leiden University College, 3595 DG The Hague, The Netherlands
6
Department of Internal Medicine, Division of Allergology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
7
Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
8
Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 7 June 2017 / Revised: 28 July 2017 / Accepted: 2 August 2017 / Published: 5 August 2017
(This article belongs to the Special Issue Nutrition and Allergic Diseases)
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Abstract

Early-life nutrition is an important modifiable determinant in the development of a child’s immune system, and may thereby influence the risk of allergic sensitization and atopic diseases. However, associations between overall dietary patterns and atopic diseases in childhood remain unclear. We examined associations of diet quality in early life with allergic sensitization, self-reported physician-diagnosed inhalant and food allergies, eczema, and asthma among 5225 children participating in a population-based cohort in the Netherlands. Diet was assessed during pregnancy, infancy, and childhood using validated food-frequency questionnaires. We calculated food-based diet quality scores (0–10 or 0–15), reflecting adherence to dietary guidelines. At age 10 years, allergic sensitization was assessed with skin prick tests. Information on physician-diagnosed inhalant and food allergies, eczema, and asthma was obtained with questionnaires. We observed no associations between diet quality during pregnancy and allergic sensitization (odds ratio (OR) = 1.05 per point in the diet score, 95% confidence interval (CI): 0.99, 1.13), allergies (0.96, 95% CI: 0.88, 1.04), eczema (0.99, 95% CI: 0.93, 1.06), or asthma (0.93, 95% CI: 0.85, 1.03) in childhood. Also, diet quality in infancy or childhood were not associated with atopic outcomes in childhood. Our findings do not support our hypothesis that a healthy dietary pattern in early life is associated with a lower risk of allergic sensitization or atopic diseases in childhood. View Full-Text
Keywords: diet quality; allergic sensitization; allergy; eczema; asthma; pregnancy; infants; cohort diet quality; allergic sensitization; allergy; eczema; asthma; pregnancy; infants; cohort
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nguyen, A.N.; Elbert, N.J.; Pasmans, S.G.M.A.; Kiefte-de Jong, J.C.; de Jong, N.W.; Moll, H.A.; Jaddoe, V.W.V.; de Jongste, J.C.; Franco, O.H.; Duijts, L.; Voortman, T. Diet Quality throughout Early Life in Relation to Allergic Sensitization and Atopic Diseases in Childhood. Nutrients 2017, 9, 841.

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