Next Article in Journal
Gluten-Free Diet Indications, Safety, Quality, Labels, and Challenges
Previous Article in Journal
Professionals’ Recommended Strategies to Improve Australian Adolescents’ Knowledge of Nutrition and Food Systems
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Nutrients 2017, 9(8), 843; doi:10.3390/nu9080843

“Omics” in Human Colostrum and Mature Milk: Looking to Old Data with New Eyes

Neonatal Intensive Care Unit, Neonatal Pathology and Neonatal Section, AOU and University of Cagliari, 09124 Cagliari, Italy
*
Author to whom correspondence should be addressed.
Received: 9 July 2017 / Revised: 2 August 2017 / Accepted: 4 August 2017 / Published: 7 August 2017
View Full-Text   |   Download PDF [330 KB, uploaded 7 August 2017]

Abstract

Human Milk (HM) is the best source for newborn nutrition until at least six months; it exerts anti-inflammatory and anti-infective functions, promotes immune system formation and supports organ development. Breastfeeding could also protect from obesity, diabetes and cardiovascular disease. Furthermore, human colostrum (HC) presents a peculiar role in newborn support as a protective effect against allergic and chronic diseases, in addition to long-term metabolic benefits. In this review, we discuss the recent literature regarding “omics” technologies and growth factors (GF) in HC and the effects of pasteurization on its composition. Our aim was to provide new evidence in terms of transcriptomics, proteomics, metabolomics, and microbiomics, also in relation to maternal metabolic diseases and/or fetal anomalies and to underline the functions of GF. Since HC results are so precious, particularly for the vulnerable pre-terms category, we also discuss the importance of HM pasteurization to ensure donated HC even to neonates whose mothers are unable to provide. To the best of our knowledge, this is the first review analyzing in detail the molecular pattern, microbiota, bioactive factors, and dynamic profile of HC, finding clinical correlations of such mediators with their possible in vivo effects and with the consequent impact on neonatal outcomes. View Full-Text
Keywords: omics technologies; human colostrum; transcriptomics; proteomics; metabolomics; microbiomics; growth factors; pasteurization; preterm newborns; neonatal intensive unit care omics technologies; human colostrum; transcriptomics; proteomics; metabolomics; microbiomics; growth factors; pasteurization; preterm newborns; neonatal intensive unit care
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bardanzellu, F.; Fanos, V.; Reali, A. “Omics” in Human Colostrum and Mature Milk: Looking to Old Data with New Eyes. Nutrients 2017, 9, 843.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top