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Nutrients 2017, 9(8), 826; doi:10.3390/nu9080826

Omega-3 Fatty Acids Supplementation Differentially Modulates the SDF-1/CXCR-4 Cell Homing Axis in Hypertensive and Normotensive Rats

1
Postgraduate Program in Health Sciences: Cardiology, Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 370, Porto Alegre, RS 90620-001, Brazil
2
Laboratory of Biodynamics, Sogipa School of Physical Education, Benjamin Constant Avenue, 80, Porto Alegre RS 90550-003, Brazil
3
Postgraduate Program in Nutrition Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Sarmento Leite Avenue, 245, Porto Alegre RS 90050-170, Brazil
*
Author to whom correspondence should be addressed.
Received: 19 June 2017 / Revised: 24 July 2017 / Accepted: 27 July 2017 / Published: 1 August 2017
(This article belongs to the Special Issue Dietary Supplements)
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Abstract

Background: We assessed the effect of acute and chronic dietary supplementation of ω-3 on lipid metabolism and cardiac regeneration, through its influence on the Stromal Derived Factor-1 (SDF-1) and its receptor (CXCR4) axis in normotensive and hypertensive rats. Methods: Male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were allocated in eight groups (of eight animals each), which received daily orogastric administration of ω-3 (1 g) for 24 h, 72 h or 2 weeks. Blood samples were collected for the analysis of the lipid profile and SDF-1 systemic levels (ELISA). At the end of the treatment period, cardiac tissue was collected for CXCR4 expression analysis (Western blot). Results: The use of ω-3 caused a reduction in total cholesterol levels (p = 0.044), and acutely activated the SDF-1/CXCR4 axis in normotensive animals (p = 0.037). In the presence of the ω-3, after 72 h, SDF-1 levels decreased in WKY and increased in SHR (p = 0.017), and tissue expression of the receptor CXCR4 was higher in WKY than in SHR (p = 0.001). Conclusion: The ω-3 fatty acid supplementation differentially modulates cell homing mediators in normotensive and hypertensive animals. While WKY rats respond acutely to omega-3 supplementation, showing increased release of SDF-1 and CXCR4, SHR exhibit a weaker, delayed response. View Full-Text
Keywords: ω-3 fatty acid; spontaneously hypertensive rats; Wistar Kyoto rats; cell homing; hypertension; Stromal Derived Factor-1; CXCR4 receptor ω-3 fatty acid; spontaneously hypertensive rats; Wistar Kyoto rats; cell homing; hypertension; Stromal Derived Factor-1; CXCR4 receptor
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Halmenschlager, L.; Lehnen, A.M.; Marcadenti, A.; Markoski, M.M. Omega-3 Fatty Acids Supplementation Differentially Modulates the SDF-1/CXCR-4 Cell Homing Axis in Hypertensive and Normotensive Rats. Nutrients 2017, 9, 826.

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