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Reply published on 23 August 2017, see Nutrients 2017, 9(9), 922.

Open AccessArticle
Nutrients 2017, 9(5), 482; doi:10.3390/nu9050482

The Impact of Diet Wheat Source on the Onset of Type 1 Diabetes Mellitus—Lessons Learned from the Non-Obese Diabetic (NOD) Mouse Model

1
Eastern Regional Research and Development Center, Judea Center, Kiryat Arba 90100, Israel
2
Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer Sheva 84990, Israel
3
Institute of Plant Sciences, ARO-Volcani Center, Rishon LeZion 50250, Israel
4
Siap Laboratory, Rehovot 76267, Israel
5
Department of Information Science and Systems, Morgan State University, Baltimore, MD 21251, USA
6
Scheller College of Business at Georgia Tech, Atlanta, GA 30308, USA
*
Author to whom correspondence should be addressed.
Received: 26 January 2017 / Revised: 20 April 2017 / Accepted: 25 April 2017 / Published: 10 May 2017
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Abstract

Nutrition, especially wheat consumption, is a major factor involved in the onset of type 1 diabetes (T1D) and other autoimmune diseases such as celiac. While modern wheat cultivars possess similar gliadin proteins associated with the onset of celiac disease and T1D, alternative dietary wheat sources from Israeli landraces and native ancestral species may be lacking the epitopes linked with T1D, potentially reducing the incidence of T1D. The Non-Obese Diabetic (NOD) mouse model was used to monitor the effects of dietary wheat sources on the onset and development of T1D. The effects of modern wheat flour were compared with those from either T. aestivum, T. turgidum spp. dicoccoides, or T. turgidum spp. dicoccum landraces or a non-wheat diet. Animals which received wheat from local landraces or ancestral species such as emmer displayed a lower incidence of T1D and related complications compared to animals fed a modern wheat variety. This study is the first report of the diabetogenic properties of various dietary wheat sources and suggests that alternative dietary wheat sources may lack T1D linked epitopes, thus reducing the incidence of T1D. View Full-Text
Keywords: type 1 diabetes mellitus; wheat; Non-Obese Diabetic (NOD) mouse; emmer; Triticum dicoccoides type 1 diabetes mellitus; wheat; Non-Obese Diabetic (NOD) mouse; emmer; Triticum dicoccoides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gorelick, J.; Yarmolinsky, L.; Budovsky, A.; Khalfin, B.; Klein, J.D.; Pinchasov, Y.; Bushuev, M.A.; Rudchenko, T.; Ben-Shabat, S. The Impact of Diet Wheat Source on the Onset of Type 1 Diabetes Mellitus—Lessons Learned from the Non-Obese Diabetic (NOD) Mouse Model. Nutrients 2017, 9, 482.

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