Role of the Enterocyte in Fructose-Induced Hypertriglyceridaemia
AbstractDietary fructose has been linked to an increased post-prandial triglyceride (TG) level; which is an established independent risk factor for cardiovascular disease. Although much research has focused on the effects of fructose consumption on liver-derived very-low density lipoprotein (VLDL); emerging evidence also suggests that fructose may raise post-prandial TG levels by affecting the metabolism of enterocytes of the small intestine. Enterocytes have become well recognised for their ability to transiently store lipids following a meal and to thus control post-prandial TG levels according to the rate of chylomicron (CM) lipoprotein synthesis and secretion. The influence of fructose consumption on several aspects of enterocyte lipid metabolism are discussed; including de novo lipogenesis; apolipoprotein B48 and CM-TG production; based on the findings of animal and human isotopic tracer studies. Methodological issues affecting the interpretation of fructose studies conducted to date are highlighted; including the accurate separation of CM and VLDL. Although the available evidence to date is limited; disruption of enterocyte lipid metabolism may make a meaningful contribution to the hypertriglyceridaemia often associated with fructose consumption. View Full-Text
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Steenson, S.; Umpleby, A.M.; Lovegrove, J.A.; Jackson, K.G.; Fielding, B.A. Role of the Enterocyte in Fructose-Induced Hypertriglyceridaemia. Nutrients 2017, 9, 349.
Steenson S, Umpleby AM, Lovegrove JA, Jackson KG, Fielding BA. Role of the Enterocyte in Fructose-Induced Hypertriglyceridaemia. Nutrients. 2017; 9(4):349.Chicago/Turabian Style
Steenson, Simon; Umpleby, A. Margot; Lovegrove, Julie A.; Jackson, Kim G.; Fielding, Barbara A. 2017. "Role of the Enterocyte in Fructose-Induced Hypertriglyceridaemia." Nutrients 9, no. 4: 349.
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