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Nutrients 2017, 9(4), 349; doi:10.3390/nu9040349

Role of the Enterocyte in Fructose-Induced Hypertriglyceridaemia

1
Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, UK
2
Department of Food & Nutritional Sciences and Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading RG6 6AP, UK
*
Author to whom correspondence should be addressed.
Received: 27 February 2017 / Revised: 21 March 2017 / Accepted: 31 March 2017 / Published: 1 April 2017
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Abstract

Dietary fructose has been linked to an increased post-prandial triglyceride (TG) level; which is an established independent risk factor for cardiovascular disease. Although much research has focused on the effects of fructose consumption on liver-derived very-low density lipoprotein (VLDL); emerging evidence also suggests that fructose may raise post-prandial TG levels by affecting the metabolism of enterocytes of the small intestine. Enterocytes have become well recognised for their ability to transiently store lipids following a meal and to thus control post-prandial TG levels according to the rate of chylomicron (CM) lipoprotein synthesis and secretion. The influence of fructose consumption on several aspects of enterocyte lipid metabolism are discussed; including de novo lipogenesis; apolipoprotein B48 and CM-TG production; based on the findings of animal and human isotopic tracer studies. Methodological issues affecting the interpretation of fructose studies conducted to date are highlighted; including the accurate separation of CM and VLDL. Although the available evidence to date is limited; disruption of enterocyte lipid metabolism may make a meaningful contribution to the hypertriglyceridaemia often associated with fructose consumption. View Full-Text
Keywords: fructose; chylomicron; very low-density lipoprotein; triglyceride-rich lipoproteins; cardiovascular disease; de novo lipogenesis; post-prandial; apoB48; gluconeogenesis; glucagon-like peptide fructose; chylomicron; very low-density lipoprotein; triglyceride-rich lipoproteins; cardiovascular disease; de novo lipogenesis; post-prandial; apoB48; gluconeogenesis; glucagon-like peptide
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MDPI and ACS Style

Steenson, S.; Umpleby, A.M.; Lovegrove, J.A.; Jackson, K.G.; Fielding, B.A. Role of the Enterocyte in Fructose-Induced Hypertriglyceridaemia. Nutrients 2017, 9, 349.

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