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Nutrients 2017, 9(4), 345; doi:10.3390/nu9040345

Daily Intake of Grape Powder Prevents the Progression of Kidney Disease in Obese Type 2 Diabetic ZSF1 Rats

1
Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H3Z6, Canada
2
Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, BC V6H3Z6, Canada
3
Department of Urology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
4
Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, BC V6Z1Y6, Canada
*
Author to whom correspondence should be addressed.
Received: 10 March 2017 / Revised: 26 March 2017 / Accepted: 29 March 2017 / Published: 31 March 2017
(This article belongs to the Special Issue Nutrition and Diet Factors in Type 2 Diabetes)
View Full-Text   |   Download PDF [4239 KB, uploaded 31 March 2017]   |  

Abstract

Individuals living with metabolic syndrome (MetS) such as diabetes and obesity are at high risk for developing chronic kidney disease (CKD). This study investigated the beneficial effect of whole grape powder (WGP) diet on MetS-associated CKD. Obese diabetic ZSF1 rats, a kidney disease model with MetS, were fed WGP (5%, w/w) diet for six months. Kidney disease was determined using blood and urine chemical analyses, and histology. When compared to Vehicle controls, WGP intake did not change the rat bodyweight, but lowered their kidney, liver and spleen weight, which were in parallel with the lower serum glucose and the higher albumin or albumin/globin ratio. More importantly, WGP intake improved the renal function as urination and proteinuria decreased, or it prevented kidney tissue damage in these diabetic rats. The renal protection of WGP diet was associated with up-regulation of antioxidants (Dhcr24, Gstk1, Prdx2, Sod2, Gpx1 and Gpx4) and downregulation of Txnip (for ROS production) in the kidneys. Furthermore, addition of grape extract reduced H2O2-induced cell death of cultured podocytes. In conclusion, daily intake of WGP reduces the progression of kidney disease in obese diabetic rats, suggesting a protective function of antioxidant-rich grape diet against CKD in the setting of MetS. View Full-Text
Keywords: metabolic syndrome; chronic kidney disease; grape powder; antioxidants; natural products; dietary supplements metabolic syndrome; chronic kidney disease; grape powder; antioxidants; natural products; dietary supplements
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Almomen, S.M.K.; Guan, Q.; Liang, P.; Yang, K.; Sidiqi, A.M.; Levin, A.; Du, C. Daily Intake of Grape Powder Prevents the Progression of Kidney Disease in Obese Type 2 Diabetic ZSF1 Rats. Nutrients 2017, 9, 345.

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