Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users
AbstractMetabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Camps, J.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; Joven, J. Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users. Nutrients 2017, 9, 121.
Luciano-Mateo F, Hernández-Aguilera A, Cabre N, Camps J, Fernández-Arroyo S, Lopez-Miranda J, Menendez JA, Joven J. Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users. Nutrients. 2017; 9(2):121.Chicago/Turabian Style
Luciano-Mateo, Fedra; Hernández-Aguilera, Anna; Cabre, Noemi; Camps, Jordi; Fernández-Arroyo, Salvador; Lopez-Miranda, Jose; Menendez, Javier A.; Joven, Jorge. 2017. "Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users." Nutrients 9, no. 2: 121.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.