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Nutrients 2017, 9(2), 121; doi:10.3390/nu9020121

Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users

1
Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain
2
Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain
3
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
4
ProCURE (Program against Cancer Therapeutic Resistance), Metabolism and Cancer Group, Catalan Institute of Oncology, 17190 Girona, Spain
5
The Campus of International Excellence Southern Catalonia, 43003 Tarragona, Spain
*
Authors to whom correspondence should be addressed.
Received: 24 November 2016 / Revised: 31 January 2017 / Accepted: 7 February 2017 / Published: 10 February 2017
(This article belongs to the Special Issue B-Vitamins and One-Carbon Metabolism)
View Full-Text   |   Download PDF [3199 KB, uploaded 15 February 2017]   |  

Abstract

Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations. View Full-Text
Keywords: diabetes mellitus; energy intake; epigenetics; folic acid; food-drug interactions; food source; obesity; vitamins B diabetes mellitus; energy intake; epigenetics; folic acid; food-drug interactions; food source; obesity; vitamins B
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Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Camps, J.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; Joven, J. Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users. Nutrients 2017, 9, 121.

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