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Nutrients 2017, 9(2), 124; doi:10.3390/nu9020124

Impact of Early Nutrition on Body Composition in Children Aged 9.5 Years Born with Extremely Low Birth Weight

1
Paediatric Endocrinology Division, Children’s Hospital, University of Bonn, 53113 Bonn, Germany
2
Department for Orthopedic surgery, Franziskus Hospital, 53545 Linz, Germany
3
Department of Radiology, Children’s Hospital, University of Bonn, 53113 Bonn, Germany
4
Department of Neonatology, Children’s Hospital, University of Bonn, 53113 Bonn, Germany
*
Author to whom correspondence should be addressed.
Received: 19 December 2016 / Revised: 27 January 2017 / Accepted: 3 February 2017 / Published: 10 February 2017
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Abstract

To evaluate body composition, metabolism and growth as well as their interaction with early nutrition in former extremely low birth weight infants (ELBW), we assessed qualitative and quantitative nutritional intake during initial hospitalization and infantile growth parameters in 61 former ELBW infants with a birth weight <1000 g. In two follow-up exams, physical and biochemical development were measured at 5.7 and at 9.5 years. At the second follow-up, in addition to biochemical reassessment, body composition was analyzed by dual-energy x-ray absorptiometry (DEXA). Protein intake between birth and discharge was associated with weight gain in the first six months of life (r = 0.51; p < 0.01). Weight catch-up preceded height catch-up. Protein intake in early infancy correlated highly significantly with abdominal fat mass (r = 0.49; p < 0.05), but not with lean body mass at 9.5 years (r = 0.30; not significant (n.s.). In contrast to nutrient intake, birth weight was associated with lean body mass (r = 0.433; p < 0.001). Early protein and carbohydrate intake were associated with high-density lipoprotein (HDL)-cholesterol, and early catch-up growth correlated with fasting insulin at follow-up. Stepwise linear regression demonstrated that protein intake predicted fat mass (p < 0.05), whereas only gender and birth weight standard deviation score (SDS) contributed significantly to lean body mass variation (p < 0.05). Our results suggest an important impact of early nutrient intake on body composition and metabolism in later childhood in ELBW children. View Full-Text
Keywords: preterm; early nutrition; body composition preterm; early nutrition; body composition
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Stutte, S.; Gohlke, B.; Peiler, A.; Schreiner, F.; Born, M.; Bartmann, P.; Woelfle, J. Impact of Early Nutrition on Body Composition in Children Aged 9.5 Years Born with Extremely Low Birth Weight. Nutrients 2017, 9, 124.

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