Next Article in Journal
Body Composition, Nutritional Profile and Muscular Fitness Affect Bone Health in a Sample of Schoolchildren from Colombia: The Fuprecol Study
Next Article in Special Issue
Gluten Contamination in Naturally or Labeled Gluten-Free Products Marketed in Italy
Previous Article in Journal
Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides
Previous Article in Special Issue
Normal Bone Mineral Density Associates with Duodenal Mucosa Healing in Adult Patients with Celiac Disease on a Gluten-Free Diet
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Nutrients 2017, 9(2), 103; doi:10.3390/nu9020103

Contact Dermatitis Due to Nickel Allergy in Patients Suffering from Non‐Celiac Wheat Sensitivity

1
Dipartimento di Biologia e Medicina Interna e Specialistica (DiBiMIS), Internal Medicine Unit, University Hospital, Palermo 90100, Italy
2
Surgery Department, University Hospital, Palermo 90100, Italy
3
Pediatric Unit, “Giovanni Paolo II” Hospital, Sciacca (ASP Agrigento) 90100, Italy
4
DiBiMIS, Gastroenterology Unit, University Hospital, Palermo 90100, Italy
5
Pediatric Gastroenterology Unit, “ARNAS Di Cristina” Hospital, Palermo 90100, Italy
6
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (Ste.Bi.CeF), University of Palermo, Palermo 90100, Italy
*
Author to whom correspondence should be addressed.
Received: 17 December 2016 / Accepted: 23 January 2017 / Published: 2 February 2017
View Full-Text   |   Download PDF [220 KB, uploaded 14 February 2017]

Abstract

Background: Non‐celiac wheat sensitivity (NCWS) is a new clinical entity in the world of gluten‐related diseases. Nickel, the most frequent cause of contact allergy, can be found in wheat and results in systemic nickel allergy syndrome and mimics irritable bowel syndrome (IBS). Objective: To evaluate the frequency of contact dermatitis due to nickel allergy in NCWS patients diagnosed by a double‐blind placebo‐controlled(DBPC)challenge,and to identify the characteristics of NCWS patients with nickel allergy. Methods: We performed a prospective study of 60 patients (54 females, 6 males; mean age 34.1 ± 8.1 years) diagnosed with NCWS from December 2014 to November 2016; 80 age‐ and sex‐matched subjects with functional gastrointestina l symptoms served as controls. Patients reporting contact dermatitis related to nickel‐containing objects underwent nickel patch test (Clinicaltrials.gov registration number: NCT02750735).Results: Six out of sixty patients (10%) with NCWS suffered from contact dermatitis and nickel allergy and this frequency was statistically higher (p = 0.04)than observed in the control group(5%. The main clinical characteristic of NCWS patients with nickel allergy was a higher frequency of cutaneous symptoms after wheat ingestion compared to NCWS patients who did not suffer from nickel allergy (p < 0.0001. Conclusions: Contact dermatitis and nickel allergy are more frequent in NCWS patients than in subjects with functional gastrointestinal disorders;furthermore, these patients had a very high frequency of cutaneous manifestations after wheat ingestion. Nickel allergy should be evaluated in NCWS patients who have cutaneous manifestations after wheat ingestion. View Full-Text
Keywords: non‐celiac  wheat  sensitivity;  nickel  allergy;  cutaneous  symptoms;  irritable  bowel  syndrome non‐celiac  wheat  sensitivity;  nickel  allergy;  cutaneous  symptoms;  irritable  bowel  syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

D’Alcamo, A.; Mansueto, P.; Soresi, M.; Iacobucci, R.; Blasca, F.L.; Geraci, G.; Cavataio, F.; Fayer, F.; Arini, A.; Di Stefano, L.; Iacono, G.; Bosco, L.; Carroccio, A. Contact Dermatitis Due to Nickel Allergy in Patients Suffering from Non‐Celiac Wheat Sensitivity. Nutrients 2017, 9, 103.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top