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Nutrients 2017, 9(2), 103; doi:10.3390/nu9020103

Contact Dermatitis Due to Nickel Allergy in Patients Suffering from Non‐Celiac Wheat Sensitivity

Dipartimento di Biologia e Medicina Interna e Specialistica (DiBiMIS), Internal Medicine Unit, University Hospital, Palermo 90100, Italy
Surgery Department, University Hospital, Palermo 90100, Italy
Pediatric Unit, “Giovanni Paolo II” Hospital, Sciacca (ASP Agrigento) 90100, Italy
DiBiMIS, Gastroenterology Unit, University Hospital, Palermo 90100, Italy
Pediatric Gastroenterology Unit, “ARNAS Di Cristina” Hospital, Palermo 90100, Italy
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (Ste.Bi.CeF), University of Palermo, Palermo 90100, Italy
Author to whom correspondence should be addressed.
Received: 17 December 2016 / Accepted: 23 January 2017 / Published: 2 February 2017
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Background: Non‐celiac wheat sensitivity (NCWS) is a new clinical entity in the world of gluten‐related diseases. Nickel, the most frequent cause of contact allergy, can be found in wheat and results in systemic nickel allergy syndrome and mimics irritable bowel syndrome (IBS). Objective: To evaluate the frequency of contact dermatitis due to nickel allergy in NCWS patients diagnosed by a double‐blind placebo‐controlled(DBPC)challenge,and to identify the characteristics of NCWS patients with nickel allergy. Methods: We performed a prospective study of 60 patients (54 females, 6 males; mean age 34.1 ± 8.1 years) diagnosed with NCWS from December 2014 to November 2016; 80 age‐ and sex‐matched subjects with functional gastrointestina l symptoms served as controls. Patients reporting contact dermatitis related to nickel‐containing objects underwent nickel patch test ( registration number: NCT02750735).Results: Six out of sixty patients (10%) with NCWS suffered from contact dermatitis and nickel allergy and this frequency was statistically higher (p = 0.04)than observed in the control group(5%. The main clinical characteristic of NCWS patients with nickel allergy was a higher frequency of cutaneous symptoms after wheat ingestion compared to NCWS patients who did not suffer from nickel allergy (p < 0.0001. Conclusions: Contact dermatitis and nickel allergy are more frequent in NCWS patients than in subjects with functional gastrointestinal disorders;furthermore, these patients had a very high frequency of cutaneous manifestations after wheat ingestion. Nickel allergy should be evaluated in NCWS patients who have cutaneous manifestations after wheat ingestion. View Full-Text
Keywords: non‐celiac  wheat  sensitivity;  nickel  allergy;  cutaneous  symptoms;  irritable  bowel  syndrome non‐celiac  wheat  sensitivity;  nickel  allergy;  cutaneous  symptoms;  irritable  bowel  syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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D’Alcamo, A.; Mansueto, P.; Soresi, M.; Iacobucci, R.; Blasca, F.L.; Geraci, G.; Cavataio, F.; Fayer, F.; Arini, A.; Di Stefano, L.; Iacono, G.; Bosco, L.; Carroccio, A. Contact Dermatitis Due to Nickel Allergy in Patients Suffering from Non‐Celiac Wheat Sensitivity. Nutrients 2017, 9, 103.

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