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Nutrients 2017, 9(11), 1176; doi:10.3390/nu9111176

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling

Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 21999, Korea
Received: 21 September 2017 / Revised: 23 October 2017 / Accepted: 24 October 2017 / Published: 27 October 2017
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Abstract

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively. mTOR controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). In addition, mTORC1 and mTORC2 regulate each other through a feedback loop to control cell growth. This review outlines the current understanding of mTOR regulation in insulin signaling in the context of whole body metabolism. View Full-Text
Keywords: insulin; mammalian target of rapamycin (mTOR); mTOR complex1 (mTORC1); mTOR complex2 (mTORC2); protein kinase B (PKB/Akt) insulin; mammalian target of rapamycin (mTOR); mTOR complex1 (mTORC1); mTOR complex2 (mTORC2); protein kinase B (PKB/Akt)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yoon, M.-S. The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling. Nutrients 2017, 9, 1176.

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