The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
AbstractThe mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively. mTOR controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). In addition, mTORC1 and mTORC2 regulate each other through a feedback loop to control cell growth. This review outlines the current understanding of mTOR regulation in insulin signaling in the context of whole body metabolism. View Full-Text
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Yoon, M.-S. The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling. Nutrients 2017, 9, 1176.
Yoon M-S. The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling. Nutrients. 2017; 9(11):1176.Chicago/Turabian Style
Yoon, Mee-Sup. 2017. "The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling." Nutrients 9, no. 11: 1176.
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