Next Article in Journal
Polyphenols and DNA Damage: A Mixed Blessing
Next Article in Special Issue
Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya
Previous Article in Journal
Dietary Compound Chrysin Inhibits Retinal Neovascularization with Abnormal Capillaries in db/db Mice
Previous Article in Special Issue
Associations of Vitamin D with Inter- and Intra-Muscular Adipose Tissue and Insulin Resistance in Women with and without Polycystic Ovary Syndrome
Article Menu

Export Article

Open AccessArticle
Nutrients 2016, 8(12), 789; doi:10.3390/nu8120789

Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis

1
Department of Dermatology, Konkuk University School of Medicine, Seoul 05030, Korea
2
Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul 05030, Korea
3
Research Institute of Medical Science, Konkuk University, Seoul 05030, Korea
*
Author to whom correspondence should be addressed.
Received: 9 August 2016 / Revised: 10 November 2016 / Accepted: 24 November 2016 / Published: 3 December 2016
(This article belongs to the Special Issue Vitamin D: Current Issues and New Perspectives)
View Full-Text   |   Download PDF [2212 KB, uploaded 3 December 2016]   |  

Abstract

Recent literature has highlighted the possible role of vitamin D in atopic dermatitis (AD), and that vitamin D supplementation might help to treat AD. This study determined the relationship between vitamin D level and AD, and assessed the efficacy of vitamin D supplementation. We searched the MEDLINE, EMBASE, and Cochrane databases up to May 2015. Observational studies and randomized controlled trials were included based on the available data on the serum 25-hydroxyvitamin D (25(OH)D) level and quantified data available for severity assessed using the Scoring Atopic Dermatitis (SCORAD) index or Eczema Area and Severity Index (EASI) score. Compared with healthy controls, the serum 25(OH)D level was lower in the AD patients of all ages (standardized mean difference = −2.03 ng/mL; 95% confidence interval (CI) = −2.52 to −0.78), and predominantly in the pediatric AD patients (standardized mean difference = −3.03 ng/mL; 95% CI = −4.76 to −1.29). In addition, the SCORAD index and EASI score decreased after vitamin D supplementation (standardized mean difference = −5.85; 95% CI = −7.66 to −4.05). This meta-analysis showed that serum vitamin D level was lower in the AD patients and vitamin D supplementation could be a new therapeutic option for AD. View Full-Text
Keywords: atopic dermatitis; vitamin D; meta-analysis; systematic review atopic dermatitis; vitamin D; meta-analysis; systematic review
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kim, M.J.; Kim, S.-N.; Lee, Y.W.; Choe, Y.B.; Ahn, K.J. Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis. Nutrients 2016, 8, 789.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top