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Nutrients 2016, 8(12), 774; doi:10.3390/nu8120774

Associations of Vitamin D with Inter- and Intra-Muscular Adipose Tissue and Insulin Resistance in Women with and without Polycystic Ovary Syndrome

1
Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton 3168, Victoria, Australia
2
Melbourne Medical School (Western Campus) and Australian Institute of Musculoskeletal Science, The University of Melbourne and Western Health, St Albans 3021, Victoria, Australia
3
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton 3168, Victoria, Australia
4
Diabetes and Vascular Medicine Unit, Monash Health, Clayton 3168, Victoria, Australia
5
Institute of Sport Exercise and Active Living, Victoria University, Melbourne 8001, Victoria, Australia
Joint senior author.
*
Author to whom correspondence should be addressed.
Received: 14 October 2016 / Revised: 9 November 2016 / Accepted: 25 November 2016 / Published: 30 November 2016
(This article belongs to the Special Issue Vitamin D: Current Issues and New Perspectives)
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Abstract

Low vitamin D and insulin resistance are common in polycystic ovary syndrome (PCOS) and associated with higher inter- and intra-muscular adipose tissue (IMAT). We investigated associations between vitamin D, IMAT and insulin resistance in a cross-sectional study of 40 women with PCOS and 30 women without PCOS, and pre- and post-exercise in a 12-week intervention in 16 overweight participants (10 with PCOS and six without PCOS). A non-classical body mass index (BMI) threshold was used to differentiate lean and overweight women (BMI ≥ 27 kg/m2). Measurements included plasma 25-hydroxyvitamin D (25OHD), insulin resistance (glucose infusion rate (GIR; mg/m2/min), fasting glucose and insulin, and glycated haemoglobin), visceral fat, mid-thigh IMAT (computed tomography) and total body fat (dual-energy X-ray absorptiometry). Women with both PCOS and low 25OHD levels had the lowest GIR (all p < 0.05). Higher IMAT was associated with lower 25OHD (B = −3.95; 95% CI −6.86, −1.05) and GIR (B = −21.3; 95% CI −37.16, −5.44) in women with PCOS. Overweight women with pre-exercise 25OHD ≥30 nmol/L had significant increases in GIR, and decreases in total and visceral fat (all p < 0.044), but no associations were observed when stratified by PCOS status. Women with PCOS and low 25OHD levels have increased insulin resistance which may be partly explained by higher IMAT. Higher pre-training 25OHD levels may enhance exercise-induced changes in body composition and insulin resistance in overweight women. View Full-Text
Keywords: polycystic ovary syndrome; insulin resistance; intramuscular adipose tissue; vitamin D; exercise; obesity polycystic ovary syndrome; insulin resistance; intramuscular adipose tissue; vitamin D; exercise; obesity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Scott, D.; Joham, A.; Teede, H.; Gibson-Helm, M.; Harrison, C.; Cassar, S.; Hutchison, S.; Ebeling, P.R.; Stepto, N.; de Courten, B. Associations of Vitamin D with Inter- and Intra-Muscular Adipose Tissue and Insulin Resistance in Women with and without Polycystic Ovary Syndrome. Nutrients 2016, 8, 774.

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