Next Article in Journal
A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women
Next Article in Special Issue
Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection
Previous Article in Journal
The Sweetener-Sensing Mechanisms of the Ghrelin Cell
Previous Article in Special Issue
Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis
Article Menu

Export Article

Open AccessArticle
Nutrients 2016, 8(12), 794; doi:10.3390/nu8120794

Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya

1
School of Biological and Physical Sciences, Maseno University, Kisumu, Kenya
2
Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya
3
Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya
4
Division of Nutritional Sciences, Cornell University, 314 Savage Hall, Ithaca, NY 14853, USA
5
African Institute for Development Policy, Nairobi, Kenya
6
Case Western Reserve University, Cleveland, OH 44106, USA
7
SUNY Upstate Medical University, Syracuse, NY 13210, USA
8
Department of Immunology and Microbiology, University of Colorado, Denver, Aurora, CO 80045, USA
*
Authors to whom correspondence should be addressed.
Received: 9 July 2016 / Revised: 7 November 2016 / Accepted: 24 November 2016 / Published: 7 December 2016
(This article belongs to the Special Issue Vitamin D: Current Issues and New Perspectives)
View Full-Text   |   Download PDF [729 KB, uploaded 7 December 2016]   |  

Abstract

Maternal plasma 25-hydroxyvitamin D (25(OH)D) status and its association with pregnancy outcomes in malaria holoendemic regions of sub-Saharan Africa is poorly defined. We examined this association and any potential interaction with malaria and helminth infections in an ongoing pregnancy cohort study in Kenya. The association of maternal plasma 25(OH)D status with pregnancy outcomes and infant anthropometric measurements at birth was determined in a subset of women (n = 63). Binomial and linear regression analyses were used to examine associations between maternal plasma 25(OH)D and adverse pregnancy outcomes. Fifty-one percent of the women had insufficient (<75 nmol/L) and 21% had deficient (<50 nmol/L) plasma 25(OH)D concentration at enrollment. At birth, 74.4% of the infants had insufficient and 30% had deficient plasma 25(OH)D concentrations, measured in cord blood. Multivariate analysis controlling for maternal age and body mass index (BMI) at enrollment and gestational age at delivery found that deficient plasma 25(OH)D levels were associated with a four-fold higher risk of stunting in neonates (p = 0.04). These findings add to the existing literature about vitamin D and its association with linear growth in resource-limited settings, though randomized clinical trials are needed to establish causation. View Full-Text
Keywords: maternal vitamin D status; pregnancy outcomes; stunting; Africa; malaria and helminth infections maternal vitamin D status; pregnancy outcomes; stunting; Africa; malaria and helminth infections
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Toko, E.N.; Sumba, O.P.; Daud, I.I.; Ogolla, S.; Majiwa, M.; Krisher, J.T.; Ouma, C.; Dent, A.E.; Rochford, R.; Mehta, S. Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya. Nutrients 2016, 8, 794.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top