Next Article in Journal
Zinc Status of Vegetarians during Pregnancy: A Systematic Review of Observational Studies and Meta-Analysis of Zinc Intake
Previous Article in Journal
Prebiotics Modulate the Effects of Antibiotics on Gut Microbial Diversity and Functioning in Vitro
Article Menu

Export Article

Open AccessArticle
Nutrients 2015, 7(6), 4498-4511; doi:10.3390/nu7064498

A Protein Extract from Chicken Reduces Plasma Homocysteine in Rats

Department of Clinical Science, University of Bergen, 5020 Bergen, Norway
Department of Heart Disease, Haukeland University Hospital, 5021 Bergen, Norway
KG Jebsen Centre for Diabetes Research, University of Bergen, 5020 Bergen, Norway
Author to whom correspondence should be addressed.
Received: 15 April 2015 / Revised: 27 May 2015 / Accepted: 29 May 2015 / Published: 4 June 2015
View Full-Text   |   Download PDF [285 KB, uploaded 4 June 2015]   |  


The present study aimed to evaluate effects of a water-soluble protein fraction of chicken (CP), with a low methionine/glycine ratio, on plasma homocysteine and metabolites related to homocysteine metabolism. Male Wistar rats were fed either a control diet with 20% w/w casein as the protein source, or an experimental diet where 6, 14 or 20% w/w of the casein was replaced with the same amount of CP for four weeks. Rats fed CP had reduced plasma total homocysteine level and markedly increased levels of the choline pathway metabolites betaine, dimethylglycine, sarcosine, glycine and serine, as well as the transsulfuration pathway metabolites cystathionine and cysteine. Hepatic mRNA level of enzymes involved in homocysteine remethylation, methionine synthase and betaine-homocysteine S-methyltransferase, were unchanged, whereas cystathionine gamma-lyase of the transsulfuration pathway was increased in the CP treated rats. Plasma concentrations of vitamin B2, folate, cobalamin, and the B-6 catabolite pyridoxic acid were increased in the 20% CP-treated rats. In conclusion, the CP diet was associated with lower plasma homocysteine concentration and higher levels of serine, choline oxidation and transsulfuration metabolites compared to a casein diet. The status of related B-vitamins was also affected by CP. View Full-Text
Keywords: chicken protein; homocysteine; one-carbon metabolism; peroxisome proliferator activated receptor; Wistar rats chicken protein; homocysteine; one-carbon metabolism; peroxisome proliferator activated receptor; Wistar rats

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lysne, V.; Bjørndal, B.; Vik, R.; Nordrehaug, J.E.; Skorve, J.; Nygård, O.; Berge, R.K. A Protein Extract from Chicken Reduces Plasma Homocysteine in Rats. Nutrients 2015, 7, 4498-4511.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top