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Nutrients 2015, 7(6), 4318-4335; doi:10.3390/nu7064318

Folate and Nutrients Involved in the 1-Carbon Cycle in the Pretreatment of Patients for Colorectal Cancer

1
Department of Pelvic Surgery, A.C. Camargo Cancer Center, Rua Professor Antônio Prudente, 211, Liberdade, São Paulo (SP) CEP 01509-010, Brazil
2
Department of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, Consolação, São Paulo (SP) CEP 01246-904, Brazil
*
Author to whom correspondence should be addressed.
Received: 8 December 2014 / Accepted: 8 May 2015 / Published: 2 June 2015
(This article belongs to the Special Issue Assessment of Nutrient Intakes)
View Full-Text   |   Download PDF [267 KB, uploaded 2 June 2015]

Abstract

To assess the ingestion of folate and nutrients involved in the 1-carbon cycle in non-treated patients with colorectal adenocarcinoma in a reference center for oncology in southeastern Brazil. In total, 195 new cases with colorectal adenocarcinoma completed a clinical evaluation questionnaire and a Food Frequency Questionnaire (FFQ). Blood samples from 161 patients were drawn for the assessment of serum folate. A moderate correlation was found between serum concentrations of folate, folate intake and the dietary folate equivalent (DFE) of synthetic supplements. Mulatto or black male patients with a primary educational level had a higher intake of dietary folate. Of patients obtaining folate from the diet alone or from dietary supplements, 11.00% and 0.10%, respectively, had intake below the recommended level. Of the patients using dietary supplements, 35% to 50% showed high levels of folic acid intake. There was a prevalence of inadequacy for vitamins B2, B6 and B12, ranging from 12.10% to 20.18%, while 13.76% to 22.55% of patients were likely to have adequate choline intake. The considerable percentage of patients with folate intake above the recommended levels deserves attention because of the harmful effects that this nutrient may have in the presence of established neoplastic lesions. View Full-Text
Keywords: folate; 1-carbon cycle; colorectal carcinogenesis. folate; 1-carbon cycle; colorectal carcinogenesis.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ferrari, A.; de Carvalho, A.M.; Steluti, J.; Teixeira, J.; Marchioni, D.M.L.; Aguiar, S., Jr. Folate and Nutrients Involved in the 1-Carbon Cycle in the Pretreatment of Patients for Colorectal Cancer. Nutrients 2015, 7, 4318-4335.

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