Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study
AbstractPrevious studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined the association between the DII and the incidence of cardiovascular disease (CVD: myocardial infarction, stroke or cardiovascular death) in the PREDIMED (Prevención con Dieta Mediterránea) study including 7216 high-risk participants. The DII was computed based on a validated 137-item food frequency questionnaire. Multivariate-adjusted hazard ratios (HR) and 95% confidence intervals of CVD risk were computed across quartiles of the DII where the lowest (most anti-inflammatory) quartile is the referent. Risk increased across the quartiles (i.e., with increasing inflammatory potential): HRquartile2 = 1.42 (95%CI = 0.97–2.09); HRquartile3 = 1.85 (1.27–2.71); and HRquartile4 = 1.73 (1.15–2.60). When fit as continuous the multiple-adjusted hazard ratio for each additional standard deviation of the DII was 1.22 (1.06–1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events. View Full-Text
Share & Cite This Article
Garcia-Arellano, A.; Ramallal, R.; Ruiz-Canela, M.; Salas-Salvadó, J.; Corella, D.; Shivappa, N.; Schröder, H.; Hébert, J.R.; Ros, E.; Gómez-Garcia, E.; Estruch, R.; Lapetra, J.; Arós, F.; Fiol, M.; Serra-Majem, L.; Pintó, X.; Babio, N.; González, J.I.; Fitó, M.; Martínez, J.A.; Martínez-González, M.A.; investigators, T.P. Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study. Nutrients 2015, 7, 4124-4138.
Garcia-Arellano A, Ramallal R, Ruiz-Canela M, Salas-Salvadó J, Corella D, Shivappa N, Schröder H, Hébert JR, Ros E, Gómez-Garcia E, Estruch R, Lapetra J, Arós F, Fiol M, Serra-Majem L, Pintó X, Babio N, González JI, Fitó M, Martínez JA, Martínez-González MA, investigators TP. Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study. Nutrients. 2015; 7(6):4124-4138.Chicago/Turabian Style
Garcia-Arellano, Ana; Ramallal, Raul; Ruiz-Canela, Miguel; Salas-Salvadó, Jordi; Corella, Dolores; Shivappa, Nitin; Schröder, Helmut; Hébert, James R.; Ros, Emilio; Gómez-Garcia, Enrique; Estruch, Ramon; Lapetra, José; Arós, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Pintó, Xavier; Babio, Nancy; González, José I.; Fitó, Montse; Martínez, J. A.; Martínez-González, Miguel A.; investigators, the P. 2015. "Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study." Nutrients 7, no. 6: 4124-4138.