Next Article in Journal
Endotoxin-Binding Peptides Derived from Casein Glycomacropeptide Inhibit Lipopolysaccharide-Stimulated Inflammatory Responses via Blockade of NF-κB activation in macrophages
Next Article in Special Issue
Low Folate and Selenium in the Mouse Maternal Diet Alters Liver Gene Expression Patterns in the Offspring after Weaning
Previous Article in Journal
Lower Protein-to-Carbohydrate Ratio in Maternal Diet is Associated with Higher Childhood Systolic Blood Pressure up to Age Four Years
Previous Article in Special Issue
Differential Acute Effects of Selenomethionine and Sodium Selenite on the Severity of Colitis
Article Menu

Export Article

Open AccessReview
Nutrients 2015, 7(5), 3094-3118; doi:10.3390/nu7053094

Selenium and Its Supplementation in Cardiovascular Disease—What do We Know?

1
Department of Thoracic and Cardiovascular Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany,
2
Department of Critical Care, Intensive Care Unit, Faculty of Medicine, Universidad de la República (UdeLaR), Italia Av. 14th floor. 11.600, Montevideo, Uruguay
3
Clinical Nutrition, College of Health, Massey University, Albany Campus Private Bag 102 904 Auckland 0632, New Zealand
4
Institute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, 52074 Aachen, Germany
5
Department of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 28 February 2015 / Revised: 7 April 2015 / Accepted: 16 April 2015 / Published: 27 April 2015
(This article belongs to the Special Issue Dietary Selenium and Human Health)
View Full-Text   |   Download PDF [510 KB, uploaded 27 April 2015]   |  

Abstract

The trace element selenium is of high importance for many of the body’s regulatory and metabolic functions. Balanced selenium levels are essential, whereas dysregulation can cause harm. A rapidly increasing number of studies characterizes the wide range of selenium dependent functions in the human body and elucidates the complex and multiple physiological and pathophysiological interactions of selenium and selenoproteins. For the majority of selenium dependent enzymes, several biological functions have already been identified, like regulation of the inflammatory response, antioxidant properties and the proliferation/differentiation of immune cells. Although the potential role of selenium in the development and progression of cardiovascular disease has been investigated for decades, both observational and interventional studies of selenium supplementation remain inconclusive and are considered in this review. This review covers current knowledge of the role of selenium and selenoproteins in the human body and its functional role in the cardiovascular system. The relationships between selenium intake/status and various health outcomes, in particular cardiomyopathy, myocardial ischemia/infarction and reperfusion injury are reviewed. We describe, in depth, selenium as a biomarker in coronary heart disease and highlight the significance of selenium supplementation for patients undergoing cardiac surgery. View Full-Text
Keywords: cardiovascular disease; coronary heart disease; cardiac surgery; selenium selenoproteins cardiovascular disease; coronary heart disease; cardiac surgery; selenium selenoproteins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Benstoem, C.; Goetzenich, A.; Kraemer, S.; Borosch, S.; Manzanares, W.; Hardy, G.; Stoppe, C. Selenium and Its Supplementation in Cardiovascular Disease—What do We Know? Nutrients 2015, 7, 3094-3118.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top