Next Article in Journal
Assessing the Nutritional Quality of Diets of Canadian Adults Using the 2014 Health Canada Surveillance Tool Tier System
Previous Article in Journal
The Overlap between Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity: A Clinical Dilemma
Previous Article in Special Issue
Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function
Article Menu

Export Article

Open AccessReview
Nutrients 2015, 7(12), 10427-10446; doi:10.3390/nu7125542

Zinc in Early Life: A Key Element in the Fetus and Preterm Neonate

Department of Gynecology-Obstetrics, University of Rome La Sapienza, Rome 00186, Italy
Department of Translational Medicine, University of Naples Federico II, Napoli 80138, Italy
Research Center on Evaluation of Quality in Medicine—CEQUAM, University of Rome La Sapienza, Rome 00186, Italy
Department of Pediatrics, University of Rome La Sapienza, Rome 00186, Italy
Author to whom correspondence should be addressed.
Received: 8 August 2015 / Revised: 23 November 2015 / Accepted: 26 November 2015 / Published: 11 December 2015
(This article belongs to the Special Issue Dietary Zinc and Human Health)
View Full-Text   |   Download PDF [1111 KB, uploaded 11 December 2015]   |  


Zinc is a key element for growth and development. In this narrative review, we focus on the role of dietary zinc in early life (including embryo, fetus and preterm neonate), analyzing consequences of zinc deficiency and adequacy of current recommendations on dietary zinc. We performed a systematic search of articles on the role of zinc in early life. We selected and analyzed 81 studies. Results of this analysis showed that preservation of zinc balance is of critical importance for the avoidance of possible consequences of low zinc levels on pre- and post-natal life. Insufficient quantities of zinc during embryogenesis may influence the final phenotype of all organs. Maternal zinc restriction during pregnancy influences fetal growth, while adequate zinc supplementation during pregnancy may result in a reduction of the risk of preterm birth. Preterm neonates are at particular risk to develop zinc deficiency due to a combination of different factors: (i) low body stores due to reduced time for placental transfer of zinc; (ii) increased endogenous losses; and (iii) marginal intake. Early diagnosis of zinc deficiency, through the measurement of serum zinc concentrations, may be essential to avoid severe prenatal and postnatal consequences in these patients. Typical clinical manifestations of zinc deficiency are growth impairment and dermatitis. Increasing data suggest that moderate zinc deficiency may have significant subclinical effects, increasing the risk of several complications typical of preterm neonates (i.e., necrotizing enterocolitis, chronic lung disease, and retinopathy), and that current recommended intakes should be revised to meet zinc requirements of extremely preterm neonates. Future studies evaluating the adequacy of current recommendations are advocated. View Full-Text
Keywords: micronutrients; neonate; newborn; fetus; low birth weight; growth; dermatitis; Necrotizing enterocolitis micronutrients; neonate; newborn; fetus; low birth weight; growth; dermatitis; Necrotizing enterocolitis

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Terrin, G.; Berni Canani, R.; Di Chiara, M.; Pietravalle, A.; Aleandri, V.; Conte, F.; De Curtis, M. Zinc in Early Life: A Key Element in the Fetus and Preterm Neonate. Nutrients 2015, 7, 10427-10446.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top