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Nutrients 2015, 7(11), 9096-9104; doi:10.3390/nu7115455

Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers

1
Laborartoire de Biologie Cellulaire & Moléculaire, Université de Constantine 1, Constantine 25000, Alegria
2
Physiologie de la Nutrition & Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup, Dijon 21000, France
3
Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czech Republic
4
Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czech Republic
5
Institute of Animal Physiology and Genetics, Academy of Science, Veveří 97, 60200 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 23 September 2015 / Revised: 18 October 2015 / Accepted: 29 October 2015 / Published: 4 November 2015
(This article belongs to the Special Issue Fatty Acids in Obesity and Type 2 Diabetes)
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Abstract

Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers. View Full-Text
Keywords: CD36; taste; obesity; adolescents; oleic acid CD36; taste; obesity; adolescents; oleic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Daoudi, H.; Plesník, J.; Sayed, A.; Šerý, O.; Rouabah, A.; Rouabah, L.; Khan, N.A. Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers. Nutrients 2015, 7, 9096-9104.

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