Next Article in Journal
In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts
Previous Article in Journal
Epigenetic Effects of Human Breast Milk
Previous Article in Special Issue
Obesity and Dyslipidemia in South Asians
Article Menu

Export Article

Open AccessReview
Nutrients 2014, 6(4), 1725-1736; doi:10.3390/nu6041725

Obesity and Lifespan Health—Importance of the Fetal Environment

1
Department of Pediatrics, School of Medicine, University of California, Davis, CA 95616, USA
2
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis 95616, CA, USA
3
California National Primate Research Center, University of California, Davis, CA 95616, USA
4
Department of Medicine, School of Medicine, University of California, Davis, CA 95616, USA
5
Department of Veterans Affairs, Northern California Health Care System, Sacramento, CA 95817, USA
*
Author to whom correspondence should be addressed.
Received: 7 January 2014 / Revised: 9 April 2014 / Accepted: 15 April 2014 / Published: 24 April 2014
(This article belongs to the Special Issue Dyslipidemia and Obesity)
View Full-Text   |   Download PDF [728 KB, uploaded 24 April 2014]   |  

Abstract

A marked increase in the frequency of obesity at the population level has resulted in an increasing number of obese women entering pregnancy. The increasing realization of the importance of the fetal environment in relation to chronic disease across the lifespan has focused attention on the role of maternal obesity in fetal development. Previous studies have demonstrated that obesity during adolescence and adulthood can be traced back to fetal and early childhood exposures. This review focuses on factors that contribute to early developmental events, such as epigenetic modifications, the potential for an increase in inflammatory burden, early developmental programming changes such as the variable development of white versus brown adipose tissue, and alterations in organ ontogeny. We hypothesize that these mechanisms promote an unfavorable fetal environment and can have a long-standing impact, with early manifestations of chronic disease that can result in an increased demand for future health care. In order to identify appropriate preventive measures, attention needs to be placed both on reducing maternal obesity as well as understanding the molecular, cellular, and epigenetic mechanisms that may be responsible for the prenatal onset of chronic disease.
Keywords: adipose tissue; pregnancy; metabolic syndrome; birth weight; risk factors; fetal environment; lifespan health adipose tissue; pregnancy; metabolic syndrome; birth weight; risk factors; fetal environment; lifespan health
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tarantal, A.F.; Berglund, L. Obesity and Lifespan Health—Importance of the Fetal Environment. Nutrients 2014, 6, 1725-1736.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top