Next Article in Journal
Vitamin A/Retinol and Maintenance of Pluripotency of Stem Cells
Previous Article in Journal
Vitamin D Intake and Status in 12-Month-Old Infants at 63–66° N
Nutrients 2014, 6(3), 1194-1208; doi:10.3390/nu6031194
Article

Curcumin Protects against Cadmium-Induced Vascular Dysfunction, Hypertension and Tissue Cadmium Accumulation in Mice

1,* , 2
, 2
, 3
, 4
 and 5
Received: 24 January 2014; in revised form: 5 March 2014 / Accepted: 12 March 2014 / Published: 21 March 2014
View Full-Text   |   Download PDF [265 KB, uploaded 21 March 2014]   |   Browse Figures
Abstract: Curcumin from turmeric is commonly used worldwide as a spice and has been demonstrated to possess various biological activities. This study investigated the protective effect of curcumin on a mouse model of cadmium (Cd)—induced hypertension, vascular dysfunction and oxidative stress. Male ICR mice were exposed to Cd (100 mg/L) in drinking water for eight weeks. Curcumin (50 or 100 mg/kg) was intragastrically administered in mice every other day concurrently with Cd. Cd induced hypertension and impaired vascular responses to phenylephrine, acetylcholine and sodium nitroprusside. Curcumin reduced the toxic effects of Cd and protected vascular dysfunction by increasing vascular responsiveness and normalizing the blood pressure levels. The vascular protective effect of curcumin in Cd exposed mice is associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein, restoration of glutathione redox ratio and alleviation of oxidative stress as indicated by decreasing superoxide production in the aortic tissues and reducing plasma malondialdehyde, plasma protein carbonyls, and urinary nitrate/nitrite levels. Curcumin also decreased Cd accumulation in the blood and various organs of Cd-intoxicated mice. These findings suggest that curcumin, due to its antioxidant and chelating properties, is a promising protective agent against hypertension and vascular dysfunction induced by Cd.
Keywords: cadmium; curcumin; hypertension; oxidative stress; vascular dysfunction cadmium; curcumin; hypertension; oxidative stress; vascular dysfunction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Kukongviriyapan, U.; Pannangpetch, P.; Kukongviriyapan, V.; Donpunha, W.; Sompamit, K.; Surawattanawan, P. Curcumin Protects against Cadmium-Induced Vascular Dysfunction, Hypertension and Tissue Cadmium Accumulation in Mice. Nutrients 2014, 6, 1194-1208.

AMA Style

Kukongviriyapan U, Pannangpetch P, Kukongviriyapan V, Donpunha W, Sompamit K, Surawattanawan P. Curcumin Protects against Cadmium-Induced Vascular Dysfunction, Hypertension and Tissue Cadmium Accumulation in Mice. Nutrients. 2014; 6(3):1194-1208.

Chicago/Turabian Style

Kukongviriyapan, Upa; Pannangpetch, Patchareewan; Kukongviriyapan, Veerapol; Donpunha, Wanida; Sompamit, Kwanjit; Surawattanawan, Praphassorn. 2014. "Curcumin Protects against Cadmium-Induced Vascular Dysfunction, Hypertension and Tissue Cadmium Accumulation in Mice." Nutrients 6, no. 3: 1194-1208.


Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert