Nutrients 2014, 6(3), 1016-1028; doi:10.3390/nu6031016
Article

Lipid-Lowering Effects of Pediococcus acidilactici M76 Isolated from Korean Traditional Makgeolli in High Fat Diet-Induced Obese Mice

1,2email, 1,2email and 1,2,* email
Received: 24 October 2013; in revised form: 15 February 2014 / Accepted: 26 February 2014 / Published: 7 March 2014
(This article belongs to the Special Issue Eating Disorder and Obesity)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The effect of Pediococcus acidilactici M76 (lactic acid bacteria) isolated from makgeolli on mice fed a high fat diet was investigated to clarify the lipid lowering function. C57BL/6J male mice were randomly divided into a normal diet (ND) group, high fat diet (HD) group, HD plus Pediococcus acidilactici DSM 20284 reference strain (PR) group, and HD plus Pediococcus acidilactici M76 strain (PA) groups. The lyophilized PA and PR strain were dissolved in distilled water at a final concentration of 1.25 × 109 cfu/mL and was given orally to animals at a dose of 4 mL/kg body weight for 12 weeks. The PA group had a lower final body weight, adipose tissue weight, and lipid profile than those in the HD group. Additionally, level of ACC, FAS and PPAR-γ, a key lipid synthesis enzyme, was markedly suppressed in the PA compared to those in the HD group. These data suggest that P. acidilactici M76 may exert a lipid-lowering effect in high fat diet- induced obese mice.
Keywords: Pediococcus acidilactici; obesity; lipid metabolism
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MDPI and ACS Style

Moon, Y.-J.; Baik, S.-H.; Cha, Y.-S. Lipid-Lowering Effects of Pediococcus acidilactici M76 Isolated from Korean Traditional Makgeolli in High Fat Diet-Induced Obese Mice. Nutrients 2014, 6, 1016-1028.

AMA Style

Moon Y-J, Baik S-H, Cha Y-S. Lipid-Lowering Effects of Pediococcus acidilactici M76 Isolated from Korean Traditional Makgeolli in High Fat Diet-Induced Obese Mice. Nutrients. 2014; 6(3):1016-1028.

Chicago/Turabian Style

Moon, Yeon-Jeong; Baik, Sang-Ho; Cha, Youn-Soo. 2014. "Lipid-Lowering Effects of Pediococcus acidilactici M76 Isolated from Korean Traditional Makgeolli in High Fat Diet-Induced Obese Mice." Nutrients 6, no. 3: 1016-1028.


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