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Nutrients 2014, 6(10), 4531-4551; doi:10.3390/nu6104531

Nutrigenomics of Body Weight Regulation: A Rationale for Careful Dissection of Individual Contributors

Human and Animal Physiology, Wageningen University, De Elst 1, 6708 WD Wageningen, The Netherlands
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Received: 16 August 2014 / Revised: 29 September 2014 / Accepted: 13 October 2014 / Published: 21 October 2014
(This article belongs to the Special Issue Nutrient: Gene Interactions)
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Abstract

Body weight stability may imply active regulation towards a certain physiological condition, a body weight setpoint. This interpretation is ill at odds with the world-wide increase in overweight and obesity. Until now, a body weight setpoint has remained elusive and the setpoint theory did not provide practical clues for body weight reduction interventions. For this an alternative theoretical model is necessary, which is available as the settling point model. The settling point model postulates that there is little active regulation towards a predefined body weight, but that body weight settles based on the resultant of a number of contributors, represented by the individual’s genetic predisposition, in interaction with environmental and socioeconomic factors, such as diet and lifestyle. This review refines the settling point model and argues that by taking body weight regulation from a settling point perspective, the road will be opened to careful dissection of the various contributors to establishment of body weight and its regulation. This is both necessary and useful. Nutrigenomic technologies may help to delineate contributors to body weight settling. Understanding how and to which extent the different contributors influence body weight will allow the design of weight loss and weight maintenance interventions, which hopefully are more successful than those that are currently available. View Full-Text
Keywords: overweight; obesity; body weight regain; body weight loss; setpoint; settling point; study design; leptin overweight; obesity; body weight regain; body weight loss; setpoint; settling point; study design; leptin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Keijer, J.; Hoevenaars, F.P.M.; Nieuwenhuizen, A.; van Schothorst, E.M. Nutrigenomics of Body Weight Regulation: A Rationale for Careful Dissection of Individual Contributors. Nutrients 2014, 6, 4531-4551.

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