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Nutrients 2014, 6(10), 4043-4057; doi:10.3390/nu6104043

Effects of Perioperative Supplementation with Omega-3 Fatty Acids on Leukotriene B4 and Leukotriene B5 Production by Stimulated Neutrophils in Patients with Colorectal Cancer: A Randomized, Placebo-Controlled Intervention Trial

1
Department of Surgical Gastroenterology, Aalborg University Hospital, 9000 Aalborg, Denmark
2
Institute of Clinical Medicine, Aarhus University Hospital, Aarhus 8000, Denmark
3
Center for Nutrition and Bowel Disease, Aalborg University Hospital, 9000 Aalborg, Denmark
4
Department of Cardiology, Center for Cardiovascular Research, Aalborg University Hospital, 9000 Aalborg, Denmark
5
National Institute for Health Research Southampton Biomedical Research Center, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton SO16 6YD, UK
6
NordSim, Center for Simulation, Skills Training, Science and Innovation, Aalborg University Hospital, 9000 Aalborg, Denmark
*
Author to whom correspondence should be addressed.
Received: 30 July 2014 / Revised: 18 September 2014 / Accepted: 19 September 2014 / Published: 29 September 2014
(This article belongs to the Special Issue Nutrition and Cancer)
View Full-Text   |   Download PDF [601 KB, uploaded 29 September 2014]   |  

Abstract

Omega-3 fatty acids (n-3 FA) may have beneficial clinical and immune-modulating effects in surgical patients. In a randomized, double-blind, prospective, placebo-controlled trial, 148 patients referred for elective colorectal cancer surgery received an n-3 FA-enriched oral nutritional supplement (ONS) providing 2.0 g of eicosapentaenoic acid (EPA) and 1.0 g of docosahexaenoic acid (DHA) per day or a standard ONS for seven days before surgery. On the day of operation, there was a significant increase in the production of leukotriene B5 (LTB5) (p < 0.01) and 5-hydroxyeicosapentaenoic acid (5-HEPE) (p < 0.01), a significant decrease in the production of leukotriene B4 (LTB4) (p < 0.01) and a trend for a decrease in the production of 5-hydroxyeicosatetraenoic acid (5-HETE) (p < 0.1) from stimulated neutrophils in the active group compared with controls. There was no association between LTB4 values and postoperative complications. In conclusion, oral n-3 FA exerts anti-inflammatory effects in surgical patients, without reducing the risk of postoperative complications. View Full-Text
Keywords: colorectal cancer; omega-3 fatty acids; immunomodulation; fish oil; leukotrienes colorectal cancer; omega-3 fatty acids; immunomodulation; fish oil; leukotrienes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sorensen, L.S.; Thorlacius-Ussing, O.; Rasmussen, H.H.; Lundbye-Christensen, S.; Calder, P.C.; Lindorff-Larsen, K.; Schmidt, E.B. Effects of Perioperative Supplementation with Omega-3 Fatty Acids on Leukotriene B4 and Leukotriene B5 Production by Stimulated Neutrophils in Patients with Colorectal Cancer: A Randomized, Placebo-Controlled Intervention Trial. Nutrients 2014, 6, 4043-4057.

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