Nutrients 2013, 5(9), 3589-3604; doi:10.3390/nu5093589
Article

Acute Effects of Different Multivitamin Mineral Preparations with and without Guaraná on Mood, Cognitive Performance and Functional Brain Activation

1 Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia 2 Bayer Consumer Care Ltd., Basel 4002, Switzerland
* Author to whom correspondence should be addressed.
Received: 8 August 2013; in revised form: 4 September 2013 / Accepted: 5 September 2013 / Published: 13 September 2013
(This article belongs to the Special Issue Cognitive Benefits of Nutrients)
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Abstract: Previous work has identified the positive effects of the acute administration of a multivitamin-guaraná preparation during an effortful executive/working memory task. Here, we aimed to differentiate the effects of multivitamins with and without guaraná and to examine the neural substrates of such effects using functional magnetic resonance imaging (fMRI). Following a double-blind, placebo-controlled, randomised, balanced crossover design, 20 participants (mean age 29 ± 5.54 years) consumed multivitamin preparations with or without guaraná (Berocca® Performance and Boost, respectively) and a placebo. Thirty minutes post-treatment, they underwent neurocognitive assessment, consisting of a 10 min Cognitive Demand Battery, with mood ratings taken immediately before and after the battery. Five additional participants underwent post-treatment fMRI scanning during Rapid Visual Information Processing and Inspection Time activation tasks. The multivitamin with guaraná treatment was associated with significantly enhanced Serial Threes performance and self-rated contentment. fMRI revealed that both multivitamin treatments increased activation in areas associated with working memory and attentional processing, with the effect being greater in the multivitamin with guaraná condition. These data confirm the acute benefits of multivitamins with guaraná on mood and cognitive performance. Furthermore, they demonstrate for the first time increased brain activation from multivitamin preparations both with and without guaraná, as measured using fMRI.
Keywords: multivitamin; guaraná; attention; working memory; mood; fMRI; neuroimaging

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MDPI and ACS Style

Scholey, A.; Bauer, I.; Neale, C.; Savage, K.; Camfield, D.; White, D.; Maggini, S.; Pipingas, A.; Stough, C.; Hughes, M. Acute Effects of Different Multivitamin Mineral Preparations with and without Guaraná on Mood, Cognitive Performance and Functional Brain Activation. Nutrients 2013, 5, 3589-3604.

AMA Style

Scholey A, Bauer I, Neale C, Savage K, Camfield D, White D, Maggini S, Pipingas A, Stough C, Hughes M. Acute Effects of Different Multivitamin Mineral Preparations with and without Guaraná on Mood, Cognitive Performance and Functional Brain Activation. Nutrients. 2013; 5(9):3589-3604.

Chicago/Turabian Style

Scholey, Andrew; Bauer, Isabelle; Neale, Chris; Savage, Karen; Camfield, David; White, David; Maggini, Silvia; Pipingas, Andrew; Stough, Con; Hughes, Matthew. 2013. "Acute Effects of Different Multivitamin Mineral Preparations with and without Guaraná on Mood, Cognitive Performance and Functional Brain Activation." Nutrients 5, no. 9: 3589-3604.

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