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2013 Update on Celiac Disease and Eosinophilic Esophagitis
Department of Gastro-Hepatology, Molinette Hospital, C.so Bramante 88, 10126 Turin, Italy
Molecular Biotechnology Center, University of Turin, 10126 Turin, Italy
* Author to whom correspondence should be addressed.
Received: 15 July 2013; in revised form: 31 July 2013 / Accepted: 1 August 2013 / Published: 22 August 2013
Abstract: Celiac disease is a chronic, immune-mediated disorder, characterized by small intestinal inflammation and villous atrophy after the ingestion of gluten by genetically susceptible individuals. Several extraintestinal manifestations have been associated to celiac disease. Eosinophilic esophagitis is a primary disorder of the esophagus characterized by upper gastrointestinal symptoms, absence of gastroesophageal reflux disease and more than 15 eosinophils per high-power field in biopsy specimens. Both celiac disease and eosinophilic esophagitis are caused by aberrant, but distinct, immune responses to ingested antigens and can be responsive to restricted food intake. The aim of this review is to assess whether there is an association between these two pathologies. In the majority of the studies examined, including the studies in pediatric population, the prevalence of eosinophilic esophagitis in subjects with celiac disease was about 10-times that of the general population. We suggest searching for eosinophilic esophagitis in all children undergoing endoscopy for suspicious celiac disease.
Keywords: celiac disease; eosinophilic esophagitis; food allergy; autoimmune disorders
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Pellicano, R.; De Angelis, C.; Ribaldone, D.G.; Fagoonee, S.; Astegiano, M. 2013 Update on Celiac Disease and Eosinophilic Esophagitis. Nutrients 2013, 5, 3329-3336.
Pellicano R, De Angelis C, Ribaldone DG, Fagoonee S, Astegiano M. 2013 Update on Celiac Disease and Eosinophilic Esophagitis. Nutrients. 2013; 5(9):3329-3336.
Pellicano, Rinaldo; De Angelis, Claudio; Ribaldone, Davide G.; Fagoonee, Sharmila; Astegiano, Marco. 2013. "2013 Update on Celiac Disease and Eosinophilic Esophagitis." Nutrients 5, no. 9: 3329-3336.