Next Article in Journal
Complex Effects of Vitamin E and Vitamin C Supplementation on in Vitro Neonatal Mononuclear Cell Responses to Allergens
Next Article in Special Issue
Life Events and the Onset of Celiac Disease from a Patient’s Perspective
Previous Article in Journal
Dietary Fructose Feeding Increases Adipose Methylglyoxal Accumulation in Rats in Association with Low Expression and Activity of Glyoxalase-2
Previous Article in Special Issue
Is Dietitian Use Associated with Celiac Disease Outcomes?
Nutrients 2013, 5(9), 3329-3336; doi:10.3390/nu5093329

2013 Update on Celiac Disease and Eosinophilic Esophagitis

1,* , 1
1 Department of Gastro-Hepatology, Molinette Hospital, Bramante 88, 10126 Turin, Italy 2 Molecular Biotechnology Center, University of Turin, 10126 Turin, Italy
* Author to whom correspondence should be addressed.
Received: 15 July 2013 / Revised: 31 July 2013 / Accepted: 1 August 2013 / Published: 22 August 2013
(This article belongs to the Special Issue Nutrition and Celiac Disease)
View Full-Text   |   Download PDF [625 KB, uploaded 22 August 2013]   |   Browse Figure


Celiac disease is a chronic, immune-mediated disorder, characterized by small intestinal inflammation and villous atrophy after the ingestion of gluten by genetically susceptible individuals. Several extraintestinal manifestations have been associated to celiac disease. Eosinophilic esophagitis is a primary disorder of the esophagus characterized by upper gastrointestinal symptoms, absence of gastroesophageal reflux disease and more than 15 eosinophils per high-power field in biopsy specimens. Both celiac disease and eosinophilic esophagitis are caused by aberrant, but distinct, immune responses to ingested antigens and can be responsive to restricted food intake. The aim of this review is to assess whether there is an association between these two pathologies. In the majority of the studies examined, including the studies in pediatric population, the prevalence of eosinophilic esophagitis in subjects with celiac disease was about 10-times that of the general population. We suggest searching for eosinophilic esophagitis in all children undergoing endoscopy for suspicious celiac disease.
Keywords: celiac disease; eosinophilic esophagitis; food allergy; autoimmune disorders celiac disease; eosinophilic esophagitis; food allergy; autoimmune disorders
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Pellicano, R.; De Angelis, C.; Ribaldone, D.G.; Fagoonee, S.; Astegiano, M. 2013 Update on Celiac Disease and Eosinophilic Esophagitis. Nutrients 2013, 5, 3329-3336.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert