Next Article in Journal
Dietary Fructose Feeding Increases Adipose Methylglyoxal Accumulation in Rats in Association with Low Expression and Activity of Glyoxalase-2
Previous Article in Journal
Linseed Dietary Fibers Reduce Apparent Digestibility of Energy and Fat and Weight Gain in Growing Rats
Previous Article in Special Issue
Impact of Docosahexaenoic Acid on Gene Expression during Osteoclastogenesis in Vitro—A Comprehensive Analysis
Article Menu

Export Article

Open AccessReview
Nutrients 2013, 5(8), 3299-3310; doi:10.3390/nu5083299

Docosahexaenoic Acid, Inflammation, and Bacterial Dysbiosis in Relation to Periodontal Disease, Inflammatory Bowel Disease, and the Metabolic Syndrome

Cleveland Clinic, Wellness Institute, 1950 Richmond Road/TR2-203, Lyndhurst, OH 44124, USA
*
Author to whom correspondence should be addressed.
Received: 2 June 2013 / Revised: 30 July 2013 / Accepted: 8 August 2013 / Published: 19 August 2013
(This article belongs to the Special Issue Docosahexaenoic Acid and Human Health)
View Full-Text   |   Download PDF [446 KB, uploaded 19 August 2013]   |  

Abstract

Docosahexaenoic acid (DHA), a long-chain omega-3 polyunsaturated fatty acid, has been used to treat a range of different conditions, including periodontal disease (PD) and inflammatory bowel disease (IBD). That DHA helps with these oral and gastrointestinal diseases in which inflammation and bacterial dysbiosis play key roles, raises the question of whether DHA may assist in the prevention or treatment of other inflammatory conditions, such as the metabolic syndrome, which have also been linked with inflammation and alterations in normal host microbial populations. Here we review established and investigated associations between DHA, PD, and IBD. We conclude that by beneficially altering cytokine production and macrophage recruitment, the composition of intestinal microbiota and intestinal integrity, lipopolysaccharide- and adipose-induced inflammation, and insulin signaling, DHA may be a key tool in the prevention of metabolic syndrome. View Full-Text
Keywords: inflammation; periodontal disease; inflammatory bowel disease; metabolic syndrome; bacterial dysbiosis; microbiome; DHA; docosahexaenoic acid; omega-3; fatty acid inflammation; periodontal disease; inflammatory bowel disease; metabolic syndrome; bacterial dysbiosis; microbiome; DHA; docosahexaenoic acid; omega-3; fatty acid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tabbaa, M.; Golubic, M.; Roizen, M.F.; Bernstein, A.M. Docosahexaenoic Acid, Inflammation, and Bacterial Dysbiosis in Relation to Periodontal Disease, Inflammatory Bowel Disease, and the Metabolic Syndrome. Nutrients 2013, 5, 3299-3310.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top