Nutrients 2013, 5(7), 2530-2550; doi:10.3390/nu5072530

The Use of Probiotic Strains in Caries Prevention: A Systematic Review

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Received: 4 June 2013; in revised form: 13 June 2013 / Accepted: 17 June 2013 / Published: 5 July 2013
(This article belongs to the Special Issue Nutrition and Oral Medicine)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This paper aims to provide a systematic review of the caries-prevention effect of probiotics in human. The hypothesis was that the administration of probiotic strains might play a role in caries lesion prevention and in the control of caries-related risk factors. The main relevant databases (Medline, Embase) were searched. Quality of the Randomized Clinical Trials (RCTs) was classified using the “Consolidated Standards of Reporting Trials” (CONSORT) checklist and the Impact Factor (IF) value of each journal was recorded. Sixty-six papers were identified, and 23 fulfilled the inclusion criteria. Only three studies had caries lesion development as outcome, all the others reported caries risk factors as interim evaluation. Using the CONSORT Score, the papers were coded as 4 excellent, 9 good and 10 poor. The mean IF value recorded was 1.438. Probiotics may play a role as antagonistic agent on mutans streptococci (MS), acidogenic/aciduric bacteria that contributes to the caries process. In two-thirds of the selected papers, probiotics have demonstrated the capacity to reduce MS counts in saliva and/or plaque in short-term. The effect of probiotics on the development of caries lesion seems encouraging, but to date, RCTs on this topic are insufficient to provide scientific clinical evidence.
Keywords: probiotics; dental caries; dental caries prevention; cariogenic bacteria; mutans streptococci; lactobacilli; plaque pH; plaque acidogenicity
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MDPI and ACS Style

Cagetti, M.G.; Mastroberardino, S.; Milia, E.; Cocco, F.; Lingström, P.; Campus, G. The Use of Probiotic Strains in Caries Prevention: A Systematic Review. Nutrients 2013, 5, 2530-2550.

AMA Style

Cagetti MG, Mastroberardino S, Milia E, Cocco F, Lingström P, Campus G. The Use of Probiotic Strains in Caries Prevention: A Systematic Review. Nutrients. 2013; 5(7):2530-2550.

Chicago/Turabian Style

Cagetti, Maria G.; Mastroberardino, Stefano; Milia, Egle; Cocco, Fabio; Lingström, Peter; Campus, Guglielmo. 2013. "The Use of Probiotic Strains in Caries Prevention: A Systematic Review." Nutrients 5, no. 7: 2530-2550.

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