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Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence?
Postgraduate Program in Gynecology, Obstetrics, and Mastology, Discipline of Adolescent Medicine, Department of Pediatrics, Botucatu School of Medicine, UNESP, São Paulo State University, Botucatu, SP 18618-970, Brazil
* Author to whom correspondence should be addressed.
Received: 24 January 2013; in revised form: 16 May 2013 / Accepted: 17 May 2013 / Published: 6 June 2013
Abstract: Obesity and osteoporosis are important global health problems characterized by increasing prevalence with high impact on morbidity and mortality. The objective of this review was to determine whether excess weight during adolescence interferes with bone mass accumulation. If bone mineral gain can be optimized during puberty, adults are less likely to suffer from the devastating complications of osteoporosis. The increased fracture risk in obese children has also been attributed to a lower bone mass for weight compared to non-obese children. Thus, adiposity present in this age group may not result in the protection of bone mass, in contrast to what has been observed in adults. However, studies involving adolescents have reported both protective and detrimental effects of obesity on bone. The results and mechanisms of these interactions are controversial and have not been fully elucidated, a fact highlighting the extreme relevance of this topic and the need to monitor intervening and interactive variables.
Keywords: adolescents; bone mineral density; obesity; osteoporosis; overweight; risk factors
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MDPI and ACS Style
Mosca, L.N.; da Silva, V.N.; Goldberg, T.B.L. Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence? Nutrients 2013, 5, 2047-2061.
Mosca LN, da Silva VN, Goldberg TBL. Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence? Nutrients. 2013; 5(6):2047-2061.
Mosca, Luciana N.; da Silva, Valéria N.; Goldberg, Tamara B.L. 2013. "Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence?" Nutrients 5, no. 6: 2047-2061.