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Heated Allergens and Induction of Tolerance in Food Allergic Children
Women's and Children's Health Research Institute, University of Adelaide, 72 King William Road, North Adelaide, SA 5006, Australia
Children's Youth and Women's Health Network, University of Adelaide, 72 King William Road, North Adelaide, SA 5006, Australia
* Author to whom correspondence should be addressed.
Received: 28 March 2013; in revised form: 15 May 2013 / Accepted: 17 May 2013 / Published: 5 June 2013
Abstract: Food allergies are one of the first manifestations of allergic disease and have been shown to significantly impact on general health perception, parental emotional distress and family activities. It is estimated that in the Western world, almost one in ten children have an IgE-mediated allergy. Cow’s milk and egg allergy are common childhood allergies. Until recently, children with food allergy were advised to avoid all dietary exposure to the allergen to which they were sensitive, in the thought that consumption would exacerbate their allergy. However, recent publications indicate that up to 70% of children with egg allergy can tolerate egg baked in a cake or muffin without apparent reaction. Likewise, up to 75% of children can tolerate baked goods containing cow’s milk, and these children demonstrate IgE and IgG4 profiles indicative of tolerance development. This article will review the current literature regarding the use of heated food allergens as immunotherapy for children with cow’s milk and egg allergy.
Keywords: egg; milk; allergy; heated allergens; tolerance; oral; immunotherapy
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Cite This Article
MDPI and ACS Style
Netting, M.; Makrides, M.; Gold, M.; Quinn, P.; Penttila, I. Heated Allergens and Induction of Tolerance in Food Allergic Children. Nutrients 2013, 5, 2028-2046.
Netting M, Makrides M, Gold M, Quinn P, Penttila I. Heated Allergens and Induction of Tolerance in Food Allergic Children. Nutrients. 2013; 5(6):2028-2046.
Netting, Merryn; Makrides, Maria; Gold, Michael; Quinn, Patrick; Penttila, Irmeli. 2013. "Heated Allergens and Induction of Tolerance in Food Allergic Children." Nutrients 5, no. 6: 2028-2046.