Nutrients 2013, 5(3), 725-749; doi:10.3390/nu5030725
Article

Selenium for the Prevention of Cutaneous Melanoma

1,2,* email, 2email, Jr. 2email, 3email, 4email, 5email, 6email, 7email, 2,8email and 2email
Received: 13 December 2012; in revised form: 17 February 2013 / Accepted: 18 February 2013 / Published: 7 March 2013
(This article belongs to the Special Issue Dietary Selenium and Health)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chemical forms of Se for prevention and treatment of melanoma. We studied the effects of Se in vitro on UV-induced oxidative stress in melanocytes, and on apoptosis and cell cycle progression in melanoma cells. In vivo, we used the HGF transgenic mouse model of UV-induced melanoma to demonstrate that topical treatment with l-selenomethionine results in a significant delay in the time required for UV-induced melanoma development, but also increases the rate of growth of those tumors once they appear. In a second mouse model, we found that oral administration of high dose methylseleninic acid significantly decreases the size of human melanoma xenografts. Our findings suggest that modestly elevation of selenium levels in the skin might risk acceleration of growth of incipient tumors. Additionally, certain Se compounds administered at very high doses could have utility for the treatment of fully-malignant tumors or prevention of recurrence.
Keywords: selenium; melanoma; selenomethionine; methylseleninic acid; HGF mouse
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MDPI and ACS Style

Cassidy, P.B.; Fain, H.D.; Cassidy, J.P., Jr.; Tran, S.M.; Moos, P.J.; Boucher, K.M.; Gerads, R.; Florell, S.R.; Grossman, D.; Leachman, S.A. Selenium for the Prevention of Cutaneous Melanoma. Nutrients 2013, 5, 725-749.

AMA Style

Cassidy PB, Fain HD, Cassidy JP, Jr, Tran SM, Moos PJ, Boucher KM, Gerads R, Florell SR, Grossman D, Leachman SA. Selenium for the Prevention of Cutaneous Melanoma. Nutrients. 2013; 5(3):725-749.

Chicago/Turabian Style

Cassidy, Pamela B.; Fain, Heidi D.; Cassidy, James P., Jr.; Tran, Sally M.; Moos, Philip J.; Boucher, Kenneth M.; Gerads, Russell; Florell, Scott R.; Grossman, Douglas; Leachman, Sancy A. 2013. "Selenium for the Prevention of Cutaneous Melanoma." Nutrients 5, no. 3: 725-749.

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