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Distribution of Selenium and Oxidative Stress in Breast Tumor-Bearing Mice
Micro-Nutrition & Biomedical Nutrition Labs, Institute of Biomedical Nutrition, Hung Kuang University, Taichung 433, Taiwan
* Author to whom correspondence should be addressed.
Received: 21 December 2012; in revised form: 29 January 2013 / Accepted: 5 February 2013 / Published: 20 February 2013
Abstract: The present study investigated the effects of breast tumors on the blood and tissue distribution of essential trace mineral selenium (Se), and oxidative stress status of mice. Female 10-week-old BALB/cByJNarl mice were randomly assigned into control (CNL) and breast tumor-bearing (TB) groups. TB mice were injected subcutaneously into the right hind thigh with 5 × 106 EMT6 mouse mammary tumor cells. After 22 days, we measured Se concentrations, Se-dependent glutathione peroxidase (GPx) activities, and malondialdehyde (MDA) products (indicator of oxidative stress) in plasma, various tissues, and plasma vascular endothelial growth factor (VEGF) concentrations. There were no significant differences in body weights and daily intake between both groups. Compared with the CNL group, TB mice have decreases in plasma Se concentrations and GPx activities, as well as higher plasma VEGF and MDA concentrations. Plasma Se concentrations were also negatively correlated with plasma MDA and VEGF concentrations. Furthermore, tissue Se concentrations and GPx activities in TB animals were lower; whereas the MDA concentrations higher in various tissues including liver, kidney, brain, lung, spleen, and thymic tissues. In conclusion, disruption of Se homeostasis critically reflects oxidative stress in target tissues, thus may increase the risk for progression of breast cancer and metastasis.
Keywords: selenium; oxidative stress; breast tumor; mice
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Guo, C.-H.; Hsia, S.; Chen, P.-C. Distribution of Selenium and Oxidative Stress in Breast Tumor-Bearing Mice. Nutrients 2013, 5, 594-607.
Guo C-H, Hsia S, Chen P-C. Distribution of Selenium and Oxidative Stress in Breast Tumor-Bearing Mice. Nutrients. 2013; 5(2):594-607.
Guo, Chih-Hung; Hsia, Simon; Chen, Pei-Chung. 2013. "Distribution of Selenium and Oxidative Stress in Breast Tumor-Bearing Mice." Nutrients 5, no. 2: 594-607.