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Hormonal Relationships to Bone Mass in Elderly Spanish Men as Influenced by Dietary Calcium and Vitamin D
Metabolic Bone Diseases Research Group, School of Nursing and Occupational Therapy, University of Extremadura, Caceres 10003, Spain
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Received: 9 July 2013; in revised form: 19 November 2013 / Accepted: 21 November 2013 / Published: 4 December 2013
Abstract: We aim to evaluate whether calcium and vitamin D intake is associated with 25-hydroxyvitamin D (25-OH-Vitamin D3) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) in independent elderly men. Serum PTH and 25-OH-Vitamin D3 were measured in 195 healthy elderly men (mean age: 73.31 ± 5.10 year). Food intake was quantified using a dietetic scale. Participants with 25-OH-Vitamin D3 levels ≥ 30 ng/mL (75 nmol/L) and a calcium intake of 800–1200 mg/day exhibited the lowest PTH levels (41.49 ± 16.72 ng/mL). The highest PTH levels (75.60 ± 14.16 ng/mL) were observed in the <30 ng/mL group 25-OH-Vitamin D3 with a calcium intake >1200 mg/day. No significant differences in the serum PTH levels based on the serum 25-OH-Vitamin D3 levels were observed among participants with a calcium intake of 800–1200 mg/day. Serum PTH was inversely correlated with serum 25-OH-Vitamin D3 in the entire patient sample (r = −0.288, p = 0.019). No differences in any of the three densitometry techniques were observed between any of the age groups in the 800–1200 mg/day and >1200 mg/day calcium intake groups. PTH levels correlate negatively with serum 25-OH-Vitamin D3 levels, and neither calcium nor vitamin D intake exert a strong influence on either of the two parameters.
Keywords: PTH; vitamin D; peripheral bone mineral density; QUS
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Moran, J.M.; Lopez-Arza, L.G.; Lavado-Garcia, J.M.; Pedrera-Canal, M.; Rey-Sanchez, P.; Rodriguez-Velasco, F.J.; Fernandez, P.; Pedrera-Zamorano, J.D. Hormonal Relationships to Bone Mass in Elderly Spanish Men as Influenced by Dietary Calcium and Vitamin D. Nutrients 2013, 5, 4924-4937.
Moran JM, Lopez-Arza LG, Lavado-Garcia JM, Pedrera-Canal M, Rey-Sanchez P, Rodriguez-Velasco FJ, Fernandez P, Pedrera-Zamorano JD. Hormonal Relationships to Bone Mass in Elderly Spanish Men as Influenced by Dietary Calcium and Vitamin D. Nutrients. 2013; 5(12):4924-4937.
Moran, Jose M.; Lopez-Arza, Luis G.; Lavado-Garcia, Jesus M.; Pedrera-Canal, Maria; Rey-Sanchez, Purificacion; Rodriguez-Velasco, Francisco J.; Fernandez, Pilar; Pedrera-Zamorano, Juan D. 2013. "Hormonal Relationships to Bone Mass in Elderly Spanish Men as Influenced by Dietary Calcium and Vitamin D." Nutrients 5, no. 12: 4924-4937.