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• Moran, V
• Stammers, A
• Medina, M
• Patel, S
• Dykes, F
• Souverein, O
• Dullemeijer, C
• Pérez-Rodrigo, C
• Serra-Majem, L
• Nissensohn, M
• Lowe, N
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• Moran, V
• Stammers, A
• Medina, M
• Patel, S
• Dykes, F
• Souverein, O
• Dullemeijer, C
• Pérez-Rodrigo, C
• Serra-Majem, L
• Nissensohn, M
• Lowe, N
• [+] on PubMed
• Moran, V
• Stammers, A
• Medina, M
• Patel, S
• Dykes, F
• Souverein, O
• Dullemeijer, C
• Pérez-Rodrigo, C
• Serra-Majem, L
• Nissensohn, M
• Lowe, N

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Nutrients 2012, 4(8), 841-858; doi:10.3390/nu4080841

Review

The Relationship between Zinc Intake and Serum/Plasma Zinc Concentration in Children: A Systematic Review and Dose-Response Meta-Analysis

Victoria Hall Moran ^1,* , Anna-Louise Stammers ² , Marisol Warthon Medina ² , Sujata Patel ² , Fiona Dykes ¹ , Olga W. Souverein ³ , Carla Dullemeijer ³ , Carmen Pérez-Rodrigo ⁴ , Lluis Serra-Majem ⁵ , Mariela Nissensohn ⁵  and Nicola M. Lowe ²

¹ Maternal & Infant Nutrition & Nurture Unit, University of Central Lancashire, Preston PR1 2HE, UK ² International Institute of Nutritional Sciences and Food Safety Studies, University of Central Lancashire, Preston PR1 2HE, UK ³ Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands ⁴ Community Nutrition Unit, Bilbao City Council, Bilbao 48001, Spain ⁵ Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria 35016, Spain

* Author to whom correspondence should be addressed.

Received: 4 May 2012; in revised form: 27 June 2012 / Accepted: 10 July 2012 / Published: 26 July 2012

(This article belongs to the Special Issue Zinc in Health and Disease)

Download PDF Full-Text [302 KB, uploaded 26 July 2012 13:50 CEST]

Abstract: Recommendations for zinc intake during childhood vary widely across Europe. The EURRECA project attempts to consolidate the basis for the definition of micronutrient requirements, taking into account relationships among intake, status and health outcomes, in order to harmonise these recommendations. Data on zinc intake and biomarkers of zinc status reported in randomised controlled trials (RCTs) can provide estimates of dose-response relationships which may be used for underpinning zinc reference values. This systematic review included all RCTs of apparently healthy children aged 1–17 years published by February 2010 which provided data on zinc intake and biomarkers of zinc status. An intake-status regression coefficient () was calculated for each individual study and calculated the overall pooled and SE () using random effects meta-analysis on a double log scale. The pooled dose-response relationship between zinc intake and zinc status indicated that a doubling of the zinc intake increased the serum/plasma zinc status by 9%. This evidence can be utilised, together with currently used balance studies and repletion/depletion studies, when setting zinc recommendations as a basis for nutrition policies.

Keywords: zinc; children; serum zinc; systematic review; dose-response; dietary recommendations; EURRECA

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