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Nutrients 2012, 4(8), 841-858; doi:10.3390/nu4080841
Review

The Relationship between Zinc Intake and Serum/Plasma Zinc Concentration in Children: A Systematic Review and Dose-Response Meta-Analysis

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Received: 4 May 2012 / Revised: 27 June 2012 / Accepted: 10 July 2012 / Published: 26 July 2012
(This article belongs to the Special Issue Zinc in Health and Disease)
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Abstract

Recommendations for zinc intake during childhood vary widely across Europe. The EURRECA project attempts to consolidate the basis for the definition of micronutrient requirements, taking into account relationships among intake, status and health outcomes, in order to harmonise these recommendations. Data on zinc intake and biomarkers of zinc status reported in randomised controlled trials (RCTs) can provide estimates of dose-response relationships which may be used for underpinning zinc reference values. This systematic review included all RCTs of apparently healthy children aged 1–17 years published by February 2010 which provided data on zinc intake and biomarkers of zinc status. An intake-status regression coefficient () was calculated for each individual study and calculated the overall pooled and SE () using random effects meta-analysis on a double log scale. The pooled dose-response relationship between zinc intake and zinc status indicated that a doubling of the zinc intake increased the serum/plasma zinc status by 9%. This evidence can be utilised, together with currently used balance studies and repletion/depletion studies, when setting zinc recommendations as a basis for nutrition policies.
Keywords: zinc; children; serum zinc; systematic review; dose-response; dietary recommendations; EURRECA zinc; children; serum zinc; systematic review; dose-response; dietary recommendations; EURRECA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Moran, V.H.; Stammers, A.-L.; Medina, M.W.; Patel, S.; Dykes, F.; Souverein, O.W.; Dullemeijer, C.; Pérez-Rodrigo, C.; Serra-Majem, L.; Nissensohn, M.; Lowe, N.M. The Relationship between Zinc Intake and Serum/Plasma Zinc Concentration in Children: A Systematic Review and Dose-Response Meta-Analysis. Nutrients 2012, 4, 841-858.

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