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Nutrients 2012, 4(7), 782-798; doi:10.3390/nu4070782
Review

Maternal Zinc Intakes and Homeostatic Adjustments during Pregnancy and Lactation

1
 and 2,*
Received: 2 June 2012; in revised form: 12 July 2012 / Accepted: 13 July 2012 / Published: 24 July 2012
(This article belongs to the Special Issue Zinc in Health and Disease)
View Full-Text   |   Download PDF [224 KB, uploaded 24 July 2012]   |   Browse Figures
Abstract: Zinc plays critical roles during embryogenesis, fetal growth, and milk secretion, which increase the zinc need for pregnancy and lactation. Increased needs can be met by increasing the dietary zinc intake, along with making homeostatic adjustments in zinc utilization. Potential homeostatic adjustments include changes in circulating zinc, increased zinc absorption, decreased zinc losses, and changes in whole body zinc kinetics. Although severe zinc deficiency during pregnancy has devastating effects, systematic reviews and meta-analysis of the effect of maternal zinc supplementation on pregnancy outcomes have consistently shown a limited benefit. We hypothesize, therefore, that zinc homeostatic adjustments during pregnancy and lactation improve zinc utilization sufficiently to provide the increased zinc needs in these stages and, therefore, mitigate immediate detrimental effects due to a low zinc intake. The specific questions addressed are the following: How is zinc utilization altered during pregnancy and lactation? Are those homeostatic adjustments influenced by maternal zinc status, dietary zinc, or zinc supplementation? These questions are addressed by critically reviewing results from published human studies on zinc homeostasis during pregnancy and lactation carried out in different populations worldwide.
Keywords: zinc; pregnancy; lactation; diet; homeostasis zinc; pregnancy; lactation; diet; homeostasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Donangelo, C.M.; King, J.C. Maternal Zinc Intakes and Homeostatic Adjustments during Pregnancy and Lactation. Nutrients 2012, 4, 782-798.

AMA Style

Donangelo CM, King JC. Maternal Zinc Intakes and Homeostatic Adjustments during Pregnancy and Lactation. Nutrients. 2012; 4(7):782-798.

Chicago/Turabian Style

Donangelo, Carmen Marino; King, Janet C. 2012. "Maternal Zinc Intakes and Homeostatic Adjustments during Pregnancy and Lactation." Nutrients 4, no. 7: 782-798.


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