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Nutrients 2012, 4(3), 208-230; doi:10.3390/nu4030208
Review

Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus

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Received: 27 February 2012; in revised form: 2 March 2012 / Accepted: 5 March 2012 / Published: 21 March 2012
(This article belongs to the Special Issue Vitamin D)
View Full-Text   |   Download PDF [697 KB, updated 23 March 2012; original version uploaded 21 March 2012]
Abstract: Despite its discovery a hundred years ago, vitamin D has emerged as one of the most controversial nutrients and prohormones of the 21st century. Its role in calcium metabolism and bone health is undisputed but its role in immune function and long-term health is debated. There are clear indicators from in vitro and animal in vivo studies that point to vitamin D’s indisputable role in both innate and adaptive immunity; however, the translation of these findings to clinical practice, including the care of the pregnant woman, has not occurred. Until recently, there has been a paucity of data from randomized controlled trials to establish clear cut beneficial effects of vitamin D supplementation during pregnancy. An overview of vitamin metabolism, states of deficiency, and the results of recent clinical trials conducted in the U.S. are presented with an emphasis on what is known and what questions remain to be answered.
Keywords: vitamin D; cholecalciferol; calcitriol; pregnancy; neonate vitamin D; cholecalciferol; calcitriol; pregnancy; neonate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wagner, C.L.; Taylor, S.N.; Dawodu, A.; Johnson, D.D.; Hollis, B.W. Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus. Nutrients 2012, 4, 208-230.

AMA Style

Wagner CL, Taylor SN, Dawodu A, Johnson DD, Hollis BW. Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus. Nutrients. 2012; 4(3):208-230.

Chicago/Turabian Style

Wagner, Carol L.; Taylor, Sarah N.; Dawodu, Adekunle; Johnson, Donna D.; Hollis, Bruce W. 2012. "Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus." Nutrients 4, no. 3: 208-230.



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