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Nutrients 2012, 4(3), 208-230; doi:10.3390/nu4030208
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Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus

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Received: 27 February 2012 / Revised: 2 March 2012 / Accepted: 5 March 2012 / Published: 21 March 2012
(This article belongs to the Special Issue Vitamin D)
View Full-Text   |   Download PDF [697 KB, 23 March 2012; original version 21 March 2012]   |   Browse Figures

Abstract

Despite its discovery a hundred years ago, vitamin D has emerged as one of the most controversial nutrients and prohormones of the 21st century. Its role in calcium metabolism and bone health is undisputed but its role in immune function and long-term health is debated. There are clear indicators from in vitro and animal in vivo studies that point to vitamin D’s indisputable role in both innate and adaptive immunity; however, the translation of these findings to clinical practice, including the care of the pregnant woman, has not occurred. Until recently, there has been a paucity of data from randomized controlled trials to establish clear cut beneficial effects of vitamin D supplementation during pregnancy. An overview of vitamin metabolism, states of deficiency, and the results of recent clinical trials conducted in the U.S. are presented with an emphasis on what is known and what questions remain to be answered.
Keywords: vitamin D; cholecalciferol; calcitriol; pregnancy; neonate vitamin D; cholecalciferol; calcitriol; pregnancy; neonate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wagner, C.L.; Taylor, S.N.; Dawodu, A.; Johnson, D.D.; Hollis, B.W. Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus. Nutrients 2012, 4, 208-230.

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