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Nutrients 2012, 4(12), 2008-2019; doi:10.3390/nu4122008
Review

Targeting Cell Signaling and Apoptotic Pathways by Luteolin: Cardioprotective Role in Rat Cardiomyocytes Following Ischemia/Reperfusion

1,2
, 1,2,*  and 2
Received: 31 October 2012; in revised form: 28 November 2012 / Accepted: 5 December 2012 / Published: 12 December 2012
(This article belongs to the Special Issue Polyphenols and Human Health)
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Abstract: Myocardial ischemia often results in damaged heart structure and function, which can be restored through ischemia/reperfusion (I/R) in most cases. However, I/R can exacerbate myocardial ischemia reperfusion injury (IRI). Luteolin, a widely distributed flavonoid, a member of a group of naturally occurring polyphenolic compounds found in many fruits, vegetables and medicinal herbs, has been reported to exhibit anti-inflammatory, antioxidant and anti-carcinogenic activities. In recent years, luteolin has been shown to play an important role in the cardioprotection of IRI. However, its role and mechanism in cardioprotection against IRI has not been clearly elucidated with respect to the apoptosis pathway. The purpose of this paper is to review luteolin’s anti-apoptotic role and mechanism following I/R in rats, and indicate luteolin as a potential candidate for preventing and treating cardiovascular diseases.
Keywords: luteolin; ischemia/reperfusion (I/R); ischemia reperfusion injury (IRI); cardiomyocytes; mechanism; apoptosis luteolin; ischemia/reperfusion (I/R); ischemia reperfusion injury (IRI); cardiomyocytes; mechanism; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xu, T.; Li, D.; Jiang, D. Targeting Cell Signaling and Apoptotic Pathways by Luteolin: Cardioprotective Role in Rat Cardiomyocytes Following Ischemia/Reperfusion. Nutrients 2012, 4, 2008-2019.

AMA Style

Xu T, Li D, Jiang D. Targeting Cell Signaling and Apoptotic Pathways by Luteolin: Cardioprotective Role in Rat Cardiomyocytes Following Ischemia/Reperfusion. Nutrients. 2012; 4(12):2008-2019.

Chicago/Turabian Style

Xu, Tongda; Li, Dongye; Jiang, Dehua. 2012. "Targeting Cell Signaling and Apoptotic Pathways by Luteolin: Cardioprotective Role in Rat Cardiomyocytes Following Ischemia/Reperfusion." Nutrients 4, no. 12: 2008-2019.



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