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Nutrients 2012, 4(12), 1887-1897; doi:10.3390/nu4121887
Article

Immunomodulatory Effects of Liriope Platyphylla Water Extract on Lipopolysaccharide-Activated Mouse Macrophage

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Received: 25 September 2012; in revised form: 9 November 2012 / Accepted: 19 November 2012 / Published: 30 November 2012
(This article belongs to the Special Issue Nutrients and Immune Function)
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Abstract: The tuber of Liriope platyphylla Wang et Tang (Liliaceae), also known as Liriopis tuber, is famous in Oriental medicine owing to its tonic, antitussive, expectorant and anti-asthmatic properties. In the present study, the effects of Liriopis tuber water extract (LP) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced cultured RAW 264.7 mouse macrophages were investigated. Nitric oxide (NO), prostaglandin E2 (PGE2) and intracellular calcium release were measured after 24 h incubation. Various cytokines and nuclear transcription factors (NF-κB and CREB) of LPS-induced RAW 264.7 were measured by a multiplex bead array assay based on xMAP technology. LP (up to 200 μg/mL) significantly decreased levels of nitric oxide (NO), interleukin (IL)-6, IL-10, IL-12p40, interferon-inducible protein-10, keratinocyte-derived chemokine, monocyte chemotactic protein-1, vascular endothelial growth factor, granulocyte macrophage-colony stimulating factor, platelet derived growth factor, PGE2, intracellular calcium, NF-κB and CREB in LPS-induced RAW 264.7 cells (p < 0.05). The results suggest that LP has immunomodulatory activity to reduce excessive immune reactions during the activation of macrophages by LPS. Further studies are needed to verify the precise mechanism regulating immunomodulatory activities of LP.
Keywords: Liriope platyphylla; immunomodulatory; macrophage; cytokine; nitric oxide; transcription factor Liriope platyphylla; immunomodulatory; macrophage; cytokine; nitric oxide; transcription factor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kim, H.K.; Lee, J.Y.; Han, H.-S.; Kim, Y.-J.; Kim, H.J.; Kim, Y.-S.; Kim, H.M.; Ko, S.-G.; An, H.-J.; Lee, Y.-J.; Park, W. Immunomodulatory Effects of Liriope Platyphylla Water Extract on Lipopolysaccharide-Activated Mouse Macrophage. Nutrients 2012, 4, 1887-1897.

AMA Style

Kim HK, Lee JY, Han H-S, Kim Y-J, Kim HJ, Kim Y-S, Kim HM, Ko S-G, An H-J, Lee Y-J, Park W. Immunomodulatory Effects of Liriope Platyphylla Water Extract on Lipopolysaccharide-Activated Mouse Macrophage. Nutrients. 2012; 4(12):1887-1897.

Chicago/Turabian Style

Kim, Hye K.; Lee, Ji Y.; Han, Hyo-Sang; Kim, Young-Jin; Kim, Hyun J.; Kim, Yoon-Sang; Kim, Hyung M.; Ko, Seong-Gyu; An, Hyo-Jin; Lee, Young-Jong; Park, Wansu. 2012. "Immunomodulatory Effects of Liriope Platyphylla Water Extract on Lipopolysaccharide-Activated Mouse Macrophage." Nutrients 4, no. 12: 1887-1897.


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