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Immunomodulatory Effects of Liriope Platyphylla Water Extract on Lipopolysaccharide-Activated Mouse Macrophage
College of Korean Medicine, Gachon University, Seongnam 461-701, Korea
College of Social Science, Joongbu University, Geumsan 312-702, Korea
College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Korea
College of Oriental Medicine, Sangji University, Wonju 220-702, Korea
* Author to whom correspondence should be addressed.
Received: 25 September 2012; in revised form: 9 November 2012 / Accepted: 19 November 2012 / Published: 30 November 2012
Abstract: The tuber of Liriope platyphylla Wang et Tang (Liliaceae), also known as Liriopis tuber, is famous in Oriental medicine owing to its tonic, antitussive, expectorant and anti-asthmatic properties. In the present study, the effects of Liriopis tuber water extract (LP) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced cultured RAW 264.7 mouse macrophages were investigated. Nitric oxide (NO), prostaglandin E2 (PGE2) and intracellular calcium release were measured after 24 h incubation. Various cytokines and nuclear transcription factors (NF-κB and CREB) of LPS-induced RAW 264.7 were measured by a multiplex bead array assay based on xMAP technology. LP (up to 200 μg/mL) significantly decreased levels of nitric oxide (NO), interleukin (IL)-6, IL-10, IL-12p40, interferon-inducible protein-10, keratinocyte-derived chemokine, monocyte chemotactic protein-1, vascular endothelial growth factor, granulocyte macrophage-colony stimulating factor, platelet derived growth factor, PGE2, intracellular calcium, NF-κB and CREB in LPS-induced RAW 264.7 cells (p < 0.05). The results suggest that LP has immunomodulatory activity to reduce excessive immune reactions during the activation of macrophages by LPS. Further studies are needed to verify the precise mechanism regulating immunomodulatory activities of LP.
Keywords: Liriope platyphylla; immunomodulatory; macrophage; cytokine; nitric oxide; transcription factor
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Kim, H.K.; Lee, J.Y.; Han, H.-S.; Kim, Y.-J.; Kim, H.J.; Kim, Y.-S.; Kim, H.M.; Ko, S.-G.; An, H.-J.; Lee, Y.-J.; Park, W. Immunomodulatory Effects of Liriope Platyphylla Water Extract on Lipopolysaccharide-Activated Mouse Macrophage. Nutrients 2012, 4, 1887-1897.
Kim HK, Lee JY, Han H-S, Kim Y-J, Kim HJ, Kim Y-S, Kim HM, Ko S-G, An H-J, Lee Y-J, Park W. Immunomodulatory Effects of Liriope Platyphylla Water Extract on Lipopolysaccharide-Activated Mouse Macrophage. Nutrients. 2012; 4(12):1887-1897.
Kim, Hye K.; Lee, Ji Y.; Han, Hyo-Sang; Kim, Young-Jin; Kim, Hyun J.; Kim, Yoon-Sang; Kim, Hyung M.; Ko, Seong-Gyu; An, Hyo-Jin; Lee, Young-Jong; Park, Wansu. 2012. "Immunomodulatory Effects of Liriope Platyphylla Water Extract on Lipopolysaccharide-Activated Mouse Macrophage." Nutrients 4, no. 12: 1887-1897.