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Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review
Department of Nutrition Science, Purdue University, 700 W State St, West Lafayette, IN 47907, USA
* Author to whom correspondence should be addressed.
Received: 17 August 2012; in revised form: 26 October 2012 / Accepted: 30 October 2012 / Published: 6 November 2012
Abstract: Vitamin D is known to increase Ca absorption in adults. However, the threshold vitamin D status to benefit Ca absorption is lower than the target vitamin D status for higher bone mineral density and lower fracture risk, pointing to another pathway for vitamin D to benefit bone. One possibility is by affecting osteoblast and osteoclasts directly. Vitamin D-related bone metabolism may also be affected by soy isoflavones, which selectively bind to the estrogen receptor β and may reduce bone loss in postmenopausal women. We discuss a possible synergistic effect of soy isoflavones and vitamin D on bone by affecting osteoblast and osteoclast formation and activity in postmenopausal women.
Keywords: vitamin D; phytoestrogen; soy isoflavones; bone; postmenopause
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Park, C.Y.; Weaver, C.M. Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review. Nutrients 2012, 4, 1610-1621.
Park CY, Weaver CM. Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review. Nutrients. 2012; 4(11):1610-1621.
Park, Clara Y.; Weaver, Connie M. 2012. "Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review." Nutrients 4, no. 11: 1610-1621.