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• Weaver, CM.
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Nutrients 2012, 4(11), 1610-1621; doi:10.3390/nu4111610

Review

Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review

Clara Y. Park and Connie M. Weaver*

Department of Nutrition Science, Purdue University, 700 W State St, West Lafayette, IN 47907, USA

* Author to whom correspondence should be addressed.

Received: 17 August 2012; in revised form: 26 October 2012 / Accepted: 30 October 2012 / Published: 6 November 2012

(This article belongs to the Special Issue Dietary Minerals)

Download PDF Full-Text [606 KB, uploaded 6 November 2012 14:20 CET]

Abstract: Vitamin D is known to increase Ca absorption in adults. However, the threshold vitamin D status to benefit Ca absorption is lower than the target vitamin D status for higher bone mineral density and lower fracture risk, pointing to another pathway for vitamin D to benefit bone. One possibility is by affecting osteoblast and osteoclasts directly. Vitamin D-related bone metabolism may also be affected by soy isoflavones, which selectively bind to the estrogen receptor β and may reduce bone loss in postmenopausal women. We discuss a possible synergistic effect of soy isoflavones and vitamin D on bone by affecting osteoblast and osteoclast formation and activity in postmenopausal women.

Keywords: vitamin D; phytoestrogen; soy isoflavones; bone; postmenopause

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