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Nutrients 2012, 4(11), 1610-1621; doi:10.3390/nu4111610

Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review

Department of Nutrition Science, Purdue University, 700 W State St, West Lafayette, IN 47907, USA
* Author to whom correspondence should be addressed.
Received: 17 August 2012 / Revised: 26 October 2012 / Accepted: 30 October 2012 / Published: 6 November 2012
(This article belongs to the Special Issue Dietary Minerals)
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Vitamin D is known to increase Ca absorption in adults. However, the threshold vitamin D status to benefit Ca absorption is lower than the target vitamin D status for higher bone mineral density and lower fracture risk, pointing to another pathway for vitamin D to benefit bone. One possibility is by affecting osteoblast and osteoclasts directly. Vitamin D-related bone metabolism may also be affected by soy isoflavones, which selectively bind to the estrogen receptor β and may reduce bone loss in postmenopausal women. We discuss a possible synergistic effect of soy isoflavones and vitamin D on bone by affecting osteoblast and osteoclast formation and activity in postmenopausal women.
Keywords: vitamin D; phytoestrogen; soy isoflavones; bone; postmenopause vitamin D; phytoestrogen; soy isoflavones; bone; postmenopause
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Park, C.Y.; Weaver, C.M. Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review. Nutrients 2012, 4, 1610-1621.

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