Nutrients 2011, 3(4), 475-490; doi:10.3390/nu3040475

Human Folate Bioavailability

1email and 2,* email
Received: 2 March 2011; in revised form: 12 April 2011 / Accepted: 14 April 2011 / Published: 18 April 2011
(This article belongs to the Special Issue Folate Metabolism and Nutrition)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The vitamin folate is recognized as beneficial health-wise in the prevention of neural tube defects, anemia, cardiovascular diseases, poor cognitive performance, and some forms of cancer. However, suboptimal dietary folate intake has been reported in a number of countries. Several national health authorities have therefore introduced mandatory food fortification with synthetic folic acid, which is considered a convenient fortificant, being cost-efficient in production, more stable than natural food folate, and superior in terms of bioavailability and bioefficacy. Other countries have decided against fortification due to the ambiguous role of synthetic folic acid regarding promotion of subclinical cancers and other adverse health effects. This paper reviews recent studies on folate bioavailability after intervention with folate from food. Our conclusions were that limited folate bioavailability data are available for vegetables, fruits, cereal products, and fortified foods, and that it is difficult to evaluate the bioavailability of food folate or whether intervention with food folate improves folate status. We recommend revising the classical approach of using folic acid as a reference dose for estimating the plasma kinetics and relative bioavailability of food folate.
Keywords: folate; folic acid; human bioavailability; intervention trials; post-dose plasma kinetics
PDF Full-text Download PDF Full-Text [348 KB, Updated Version, uploaded 19 April 2011 16:34 CEST]
The original version is still available [360 KB, uploaded 18 April 2011 11:06 CEST]

Export to BibTeX |

MDPI and ACS Style

Ohrvik, V.E.; Witthoft, C.M. Human Folate Bioavailability. Nutrients 2011, 3, 475-490.

AMA Style

Ohrvik VE, Witthoft CM. Human Folate Bioavailability. Nutrients. 2011; 3(4):475-490.

Chicago/Turabian Style

Ohrvik, Veronica E.; Witthoft, Cornelia M. 2011. "Human Folate Bioavailability." Nutrients 3, no. 4: 475-490.

Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert