Abstract: Periconceptional intake of folic acid is known to reduce a woman’s risk of having an infant affected by a neural tube birth defect (NTD). National programs to mandate fortification of food with folic acid have reduced the prevalence of NTDs worldwide. Uncertainty surrounding possible unintended consequences has led to concerns about higher folic acid intake and food fortification programs. This uncertainty emphasizes the need to continually monitor fortification programs for accurate measures of their effect and the ability to address concerns as they arise. This review highlights the history, effect, concerns, and future directions of folic acid food fortification programs.
Keywords: folic acid; flour fortification; neural tube defects; cancer; epigenetics
Export to BibTeX
MDPI and ACS Style
Crider, K.S.; Bailey, L.B.; Berry, R.J. Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions. Nutrients 2011, 3, 370-384.
Crider KS, Bailey LB, Berry RJ. Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions. Nutrients. 2011; 3(3):370-384.
Crider, Krista S.; Bailey, Lynn B.; Berry, Robert J. 2011. "Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions." Nutrients 3, no. 3: 370-384.