Next Article in Journal
Vitamin A Metabolism: An Update
Next Article in Special Issue
Folate Production by Probiotic Bacteria
Previous Article in Journal
Higher Diet Quality Does Not Predict Lower Medicare Costs but Does Predict Number of Claims in Mid-Aged Australian Women
Nutrients 2011, 3(1), 49-62; doi:10.3390/nu3010049
Article

Folate Status of Reproductive Age Women and Neural Tube Defect Risk: The Effect of Long-Term Folic Acid Supplementation at Doses of 140 µg and 400 µg per Day

1
, 2
, 1
, 1
 and 1,*
Received: 22 November 2010; in revised form: 13 December 2010 / Accepted: 7 January 2011 / Published: 10 January 2011
(This article belongs to the Special Issue Folate Metabolism and Nutrition)
View Full-Text   |   Download PDF [216 KB, uploaded 10 January 2011]   |   Browse Figures
Abstract: Primary prevention of most folate-responsive neural tube defects (NTDs) may not require 400 μg folic acid/day but may be achieved by attaining a high maternal folate status. Using RBC folate ≥ 906 nmol/L as a marker for NTD risk reduction, the study aimed to determine the change in blood folate concentrations in reproductive age women in response to long-term folic acid supplementation at 400 µg/day and 140 µg/day (dose designed to mimic the average daily folic acid intake received from New Zealand’s proposed mandatory bread fortification program). Participants were randomly assigned to a daily folic acid supplement of 140 µg (n = 49), 400 µg (n = 48) or placebo (n = 47) for 40 weeks. RBC folate concentrations were measured at baseline, and after 6, 12, 29 and 40 weeks. At 40 weeks, the overall prevalence of having a RBC folate < 906 nmol/L decreased to 18% and 35% in the 400 µg and 140 µg groups, respectively, while remaining relatively unchanged at 58% in the placebo group. After 40 weeks, there was no evidence of a difference in RBC folate between the two treatment groups (P = 0.340), nor was there evidence of a difference in the odds of a RBC folate < 906 nmol/L (P = 0.078). In conclusion, the average daily intake of folic acid received from the proposed fortification program would increase RBC folate concentrations in reproductive age women to levels associated with a low risk of NTDs.
Keywords: neural tube defects; blood folate status; folic acid fortification; supplementation neural tube defects; blood folate status; folic acid fortification; supplementation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Hursthouse, N.A.; Gray, A.R.; Miller, J.C.; Rose, M.C.; Houghton, L.A. Folate Status of Reproductive Age Women and Neural Tube Defect Risk: The Effect of Long-Term Folic Acid Supplementation at Doses of 140 µg and 400 µg per Day. Nutrients 2011, 3, 49-62.

AMA Style

Hursthouse NA, Gray AR, Miller JC, Rose MC, Houghton LA. Folate Status of Reproductive Age Women and Neural Tube Defect Risk: The Effect of Long-Term Folic Acid Supplementation at Doses of 140 µg and 400 µg per Day. Nutrients. 2011; 3(1):49-62.

Chicago/Turabian Style

Hursthouse, Nicola A.; Gray, Andrew R.; Miller, Jody C.; Rose, Meredith C.; Houghton, Lisa A. 2011. "Folate Status of Reproductive Age Women and Neural Tube Defect Risk: The Effect of Long-Term Folic Acid Supplementation at Doses of 140 µg and 400 µg per Day." Nutrients 3, no. 1: 49-62.


Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert