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Nutrients 2011, 3(1), 27-39; doi:10.3390/nu3010027
Review

Vitamin A Metabolism and Adipose Tissue Biology

 and
*
Department of Medicine and the Institute of Human Nutrition, Columbia University, 630 W 168th Street, P&S 1512, New York, NY 10032, USA
* Author to whom correspondence should be addressed.
Received: 20 November 2010 / Revised: 14 December 2010 / Accepted: 5 January 2011 / Published: 6 January 2011
(This article belongs to the Special Issue Vitamin A Update)
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Abstract

In recent years, the importance of vitamin A in adipose tissue biology, obesity and type II diabetes has become apparent. This review focuses on recent developments within the area of vitamin A and adipose tissue biology. Adipose tissue has an active vitamin A metabolism as it not only stores vitamin A but retinol is also converted to its active metabolite retinoic acid. Several mouse models point to a relationship between vitamin A metabolism and the development of adiposity. Similarly, in vitro studies provide new molecular mechanisms for the function of different forms of vitamin A and retinol- or retinoic acid-binding proteins in adipose tissue.
Keywords: retinol; retinoic acid; adipose tissue; cellular retinol-binding protein; beta-carotene; adipogenesis retinol; retinoic acid; adipose tissue; cellular retinol-binding protein; beta-carotene; adipogenesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Frey, S.K.; Vogel, S. Vitamin A Metabolism and Adipose Tissue Biology. Nutrients 2011, 3, 27-39.

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