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Vitamin A Metabolism and Adipose Tissue Biology
Department of Medicine and the Institute of Human Nutrition, Columbia University, 630 W 168th Street, P&S 1512, New York, NY 10032, USA
* Author to whom correspondence should be addressed.
Received: 20 November 2010; in revised form: 14 December 2010 / Accepted: 5 January 2011 / Published: 6 January 2011
Abstract: In recent years, the importance of vitamin A in adipose tissue biology, obesity and type II diabetes has become apparent. This review focuses on recent developments within the area of vitamin A and adipose tissue biology. Adipose tissue has an active vitamin A metabolism as it not only stores vitamin A but retinol is also converted to its active metabolite retinoic acid. Several mouse models point to a relationship between vitamin A metabolism and the development of adiposity. Similarly, in vitro studies provide new molecular mechanisms for the function of different forms of vitamin A and retinol- or retinoic acid-binding proteins in adipose tissue.
Keywords: retinol; retinoic acid; adipose tissue; cellular retinol-binding protein; beta-carotene; adipogenesis
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MDPI and ACS Style
Frey, S.K.; Vogel, S. Vitamin A Metabolism and Adipose Tissue Biology. Nutrients 2011, 3, 27-39.
Frey SK, Vogel S. Vitamin A Metabolism and Adipose Tissue Biology. Nutrients. 2011; 3(1):27-39.
Frey, Simone K.; Vogel, Silke. 2011. "Vitamin A Metabolism and Adipose Tissue Biology." Nutrients 3, no. 1: 27-39.