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Nutrients 2011, 3(1), 27-39; doi:10.3390/nu3010027
Review

Vitamin A Metabolism and Adipose Tissue Biology

 and
*
Department of Medicine and the Institute of Human Nutrition, Columbia University, 630 W 168th Street, P&S 1512, New York, NY 10032, USA
* Author to whom correspondence should be addressed.
Received: 20 November 2010 / Revised: 14 December 2010 / Accepted: 5 January 2011 / Published: 6 January 2011
(This article belongs to the Special Issue Vitamin A Update)
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Abstract

In recent years, the importance of vitamin A in adipose tissue biology, obesity and type II diabetes has become apparent. This review focuses on recent developments within the area of vitamin A and adipose tissue biology. Adipose tissue has an active vitamin A metabolism as it not only stores vitamin A but retinol is also converted to its active metabolite retinoic acid. Several mouse models point to a relationship between vitamin A metabolism and the development of adiposity. Similarly, in vitro studies provide new molecular mechanisms for the function of different forms of vitamin A and retinol- or retinoic acid-binding proteins in adipose tissue.
Keywords: retinol; retinoic acid; adipose tissue; cellular retinol-binding protein; beta-carotene; adipogenesis retinol; retinoic acid; adipose tissue; cellular retinol-binding protein; beta-carotene; adipogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Frey, S.K.; Vogel, S. Vitamin A Metabolism and Adipose Tissue Biology. Nutrients 2011, 3, 27-39.

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