Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Nutrients 2010, 2(8), 790-804; doi:10.3390/nu2080790
Review

Effect of Long-Chain Polyunsaturated Fatty Acid Supplementation on Neurodevelopmental Outcome in Full-Term Infants

Received: 17 June 2010; in revised form: 6 July 2010 / Accepted: 15 July 2010 / Published: 27 July 2010
(This article belongs to the Special Issue Paediatric Nutrition and Metabolism)
View Full-Text   |   Download PDF [222 KB, uploaded 27 July 2010]
Abstract: It takes more than 20 years before the human brain obtains its complex, adult configuration. Most dramatic developmental changes occur prenatally and early postnatally. During development, long-chain polyunsaturated fatty acids (LCPUFA) such as doxosahexaenoic acid (DHA) and arachidonic acid (AA) are accreted in the brain. Since breastfeeding is associated with a better developmental outcome than formula feeding, and human milk in contrast to traditional standard formula contains LCPUFA, the question arose whether LCPUFA supplementation of infant formula may promote the neurodevelopmental outcome. The current paper reviews the evidence available in full-term infants. It concludes that postnatal supplementation of formula with LCPUFA is associated with a beneficial effect on short-term neurodevelopmental outcome. However, no evidence is available that LCPUFA supplementation enhances neurodevelopmental outcome in full-term infants beyond the age of four months. Nevertheless, it should be realized that very limited information is available on the effect of LCPUFA supplementation on neurodevelopmental outcome at school age or later. It is conceivable that effects of LCPUFA supplementation first emerge or re-emerge at school age when more complex neural functions are expressed.
Keywords: LCPUFA; docosahexaenoic acid; arachidonic acid; full-term; infant; neurodevelopment; cognition; breast feeding LCPUFA; docosahexaenoic acid; arachidonic acid; full-term; infant; neurodevelopment; cognition; breast feeding
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Hadders-Algra, M. Effect of Long-Chain Polyunsaturated Fatty Acid Supplementation on Neurodevelopmental Outcome in Full-Term Infants. Nutrients 2010, 2, 790-804.

AMA Style

Hadders-Algra M. Effect of Long-Chain Polyunsaturated Fatty Acid Supplementation on Neurodevelopmental Outcome in Full-Term Infants. Nutrients. 2010; 2(8):790-804.

Chicago/Turabian Style

Hadders-Algra, Mijna. 2010. "Effect of Long-Chain Polyunsaturated Fatty Acid Supplementation on Neurodevelopmental Outcome in Full-Term Infants." Nutrients 2, no. 8: 790-804.



Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert