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Nutrients 2010, 2(6), 626-651; doi:10.3390/nu2060626

Micronutrients, N-Acetyl Cysteine, Probiotics and Prebiotics, a Review of Effectiveness in Reducing HIV Progression

1
Department of Public Health, Erasmus MC University Medical Center Rotterdam P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
2
Canadian Research & Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, N6A 4V2, London, Ontario, Canada
3
Division of Food and Nutritional Sciences at Brescia University College, The University of Western Ontario, 1285 Western Road, N6G 1H2, London, Ontario, Canada
4
Departments of Microbiology & Immunology and Surgery, The University of Western Ontario, 1151 Richmond Street, N6A 3K7, London, Ontario, Canada
*
Author to whom correspondence should be addressed.
Received: 29 April 2010 / Revised: 18 May 2010 / Accepted: 25 May 2010 / Published: 2 June 2010
(This article belongs to the Special Issue Food and Function 2009)
View Full-Text   |   Download PDF [274 KB, uploaded 2 June 2010]

Abstract

Low serum concentrations of micronutrients, intestinal abnormalities, and an inflammatory state have been associated with HIV progression. These may be ameliorated by micronutrients, N-acetyl cysteine, probiotics, and prebiotics. This review aims to integrate the evidence from clinical trials of these interventions on the progression of HIV. Vitamin B, C, E, and folic acid have been shown to delay the progression of HIV. Supplementation with selenium, N-acetyl cysteine, probiotics, and prebiotics has considerable potential, but the evidence needs to be further substantiated. Vitamin A, iron, and zinc have been associated with adverse effects and caution is warranted for their use.
Keywords: HIV; AIDS; micronutrients; zinc; selenium; N-acetyl cysteine; probiotics; prebiotics HIV; AIDS; micronutrients; zinc; selenium; N-acetyl cysteine; probiotics; prebiotics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hummelen, R.; Hemsworth, J.; Reid, G. Micronutrients, N-Acetyl Cysteine, Probiotics and Prebiotics, a Review of Effectiveness in Reducing HIV Progression. Nutrients 2010, 2, 626-651.

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