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Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR
Department of Biotechnology, University of Natural Resources and Applied Life Sciences Vienna, Muthgasse 18, 1190 Vienna, Austria
Christian-Doppler-Laboratory of Receptor Biotechnology, Muthgasse 18, 1190 Vienna, Austria
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 21 December 2009 / Accepted: 23 February 2010 / Published: 26 February 2010
Abstract: Isoflavones have multiple actions on cell functions. The most prominent one is the activation of estrogen receptors. Other functions are often overlooked, but are equally important and explain the beneficial health effects of isoflavones. Isoflavones are potent dual PPARα/γ agonists and exert anti-inflammatory activity, which may contribute to the prevention of metabolic syndrome, atherosclerosis and various other inflammatory diseases. Some isoflavones are potent aryl hydrocarbon receptor (AhR) agonists and induce cell cycle arrest, chemoprevention and modulate xenobiotic metabolism. This review discusses effects mediated by the activation of AhR and PPARs and casts a light on the concerted action of isoflavones.
Keywords: isoflavones; PPARα; PPARγ; AhR; inflammation; metabolic syndrome; atherosclerosis; cell cycle control; xenobiotic metabolism
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MDPI and ACS Style
Medjakovic, S.; Mueller, M.; Jungbauer, A. Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR. Nutrients 2010, 2, 241-279.
Medjakovic S, Mueller M, Jungbauer A. Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR. Nutrients. 2010; 2(3):241-279.
Medjakovic, Svjetlana; Mueller, Monika; Jungbauer, Alois. 2010. "Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR." Nutrients 2, no. 3: 241-279.