Next Article in Journal
1H NMR Fingerprinting of Soybean Extracts, with Emphasis on Identification and Quantification of Isoflavones
Next Article in Special Issue
Early Exposure to Soy Isoflavones and Effects on Reproductive Health: A Review of Human and Animal Studies
Previous Article in Journal
Continuous Feedings of Fortified Human Milk Lead to Nutrient Losses of Fat, Calcium and Phosphorous
Previous Article in Special Issue
Assessment of Information to Substantiate a Health Claim on the Prevention of Prostate Cancer by Lignans
Nutrients 2010, 2(3), 241-279; doi:10.3390/nu2030241
Review

Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR

1,2,†
,
1,2,†
 and
1,2,*
Received: 21 December 2009 / Accepted: 23 February 2010 / Published: 26 February 2010
(This article belongs to the Special Issue Isoflavones and Lignans)
View Full-Text   |   Download PDF [241 KB, uploaded 26 February 2010]   |   Browse Figures

Abstract

Isoflavones have multiple actions on cell functions. The most prominent one is the activation of estrogen receptors. Other functions are often overlooked, but are equally important and explain the beneficial health effects of isoflavones. Isoflavones are potent dual PPARα/γ agonists and exert anti-inflammatory activity, which may contribute to the prevention of metabolic syndrome, atherosclerosis and various other inflammatory diseases. Some isoflavones are potent aryl hydrocarbon receptor (AhR) agonists and induce cell cycle arrest, chemoprevention and modulate xenobiotic metabolism. This review discusses effects mediated by the activation of AhR and PPARs and casts a light on the concerted action of isoflavones.
Keywords: isoflavones; PPARα; PPARγ; AhR; inflammation; metabolic syndrome; atherosclerosis; cell cycle control; xenobiotic metabolism isoflavones; PPARα; PPARγ; AhR; inflammation; metabolic syndrome; atherosclerosis; cell cycle control; xenobiotic metabolism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Medjakovic, S.; Mueller, M.; Jungbauer, A. Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR. Nutrients 2010, 2, 241-279.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert